Novel Inhibitors of Matrix Metalloproteinase-9 for Anti-Cancer Drug Development
Inhibitors that target a site on MMP-9's hemopexin domain that are distinct and cannot be functionally substituted for one another. Background: Matrix Metalloproteinase-9 (MMP-9), a type IV collagenase, is linked to cancer progression and metastasis. Despite increased evidence of correlation between MMP-9 and tumor metastasis, no success has been...
Published: 2/28/2024
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Inventor(s): Vincent Alford, Anushree Kamath, Jian Cao, Nicole Sampson, Iwao Ojima, Xiaodong Ren
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Research Tools and Reagents
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Triazibe-Based Tripod Linker System for Drug Delivery and Diagnosis
This tumor-targeted drug delivery system uses biotin as a tumor targeting moiety and taxoid-camptothecin combination. Background: Combination therapy is the primary treatment option against cancer, because multiple agents in combination, synergistically improve efficacy and are less prone to resistance due to their distinct action mechanisms. Despite...
Published: 2/28/2024
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Inventor(s): Iwao Ojima, Jacob Vineberg, Tao Wang
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Technology Classifications > Diagnostics, Technology Classifications > Therapeutics
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Asymmetric Bow-Tie Dendrimers as Versatile Platform for Drug Delivery and Diagnosis
Novel multifunctional asymmetric bow-tie dendrimers as a robust platform for drug delivery systems and diagnostic agents. Background: Dendrimers are nano-sized globular macromolecules that have been well studied as a drug delivery vehicles. Their convenient synthesis strategy, easy functionalization of the terminal end group and versatility in designing,...
Published: 2/28/2024
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Inventor(s): Iwao Ojima, Yu Han Gary Teng, Tao Wang
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics, Technology Classifications > Research Tools and Reagents
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Next-Generation Taxoids
Novel fluorine-containing taxoids with high potency against drug-resistant cancer.
Background:
Paclitaxel and docetaxel have been extensively used in clinic for treatment of various cancers. However, their lack of tumor-specificity frequently results in an assortment of undesired side effects and exhibit little efficacy in treating melanoma, pancreatic,...
Published: 11/22/2023
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Inventor(s): Iwao Ojima, Changwei Wang, Xin Wang
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Therapeutics
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Benzimidazoles and Pharmaceutical Compositions Thereof
A novel cell division inhibitor with efficacy against Mycobacterium tuberculosis Background: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant TB (XDR-TB) are a significant public health threat for TB control efforts. Despite efforts in last 50 years, development of new TB treatments have been limited to drug targets like...
Published: 11/22/2023
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Inventor(s): Iwao Ojima, Seung-Yub Lee
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Therapeutics
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