Production of Salivary Gland Epithelial Progenitors and Acinar Organoids
Human UPSC-based tissue engineering system to develop salivary gland epithelial progenitors used to construct acinar organoids that mimic glandular microarchitecture and function.
Background:
Organoids are three-dimensional cell constructs that replicate the complicated tissue microarchitecture of specialized epithelial tissues. These constructs...
Published: 3/8/2024
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Inventor(s): Stelios Andreadis, Ronel Samuel, Olga Baker, Kihoon Nam
Keywords(s): Biomedical Engineering, Biotechnology, Featured, Medical Devices, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Screens and Assays
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Compositions and Methods to Promote Endothelialization of Cardiovascular Implants
Provided here are fusion proteins that, when immobilized on the (blood-facing) surface of a cardiovascular implant, promote endothelialization, which is critical for long-term biocompatibility.
Background:
A major challenge to the clinical utilization and success of off-the-shelf vascular grafts (e.g. decellularized, devitalized and non-biologic/polymeric...
Published: 2/2/2024
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Inventor(s): Stelios Andreadis, Randall Smith, Bita Nasiri
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering
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Shear-Thinning Hydrogels
Shear-thinning, biocompatible hydrogels that are useful for cell therapy and which hold promise for 3D printing of functional tissue constructs.
Background:
While hydrogels hold great promise in applications such as drug delivery and tissue engineering, their fast gelation kinetics restrict their use in injectable applications such as the delivery...
Published: 2/7/2024
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Inventor(s): Stelios Andreadis, Mohamed Mohamed
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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