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Discovery of Novel SHIP1 Agonists

A new class of SHIP1 agonists that offer the potential for the development of new treatments for a variety of diseases. Background: An agonist is a drug or substance that binds to a cell receptor, producing the same action as the substance that would naturally bind to the receptor. Agonists form the basis for a wide variety of therapeutics. The...
Published: 5/10/2024   |   Inventor(s): William Kerr, Sandra Denney
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Artificial Intelligence, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare

Small Molecule Inhibitors for Alzheimer's Immunotherapy

Pan-SHIP1/2 inhibitors enhance phagocytosis of dead neurons and amyloid beta by microglia. Background: The beta-amyloid (1-42) peptide fragment is a crucial component of beta-amyloid debris that forms plaques in Alzheimer's Disease, playing a significant role in disease pathology and cognitive decline. Increased amyloid deposits and tau tangles...
Published: 7/11/2023   |   Inventor(s): William Kerr, Chiara Pedicone
Keywords(s): TAF, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Biomarker Diagnostic for Crohn's Disease Severity

A novel messenger RNA transcript for prediction of ulcerative colitis and Crohn's disease severity. Background: More than 2 million individuals are diagnosed with Crohn's Disease (CD) and Ulcerative Colitis (UC) in the US every year. While much progress has been made in understanding these diseases, the causes are not fully known and effective...
Published: 2/26/2024   |   Inventor(s): William Kerr, Frank Middleton, Sandra Denney
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Campus > Upstate Medical University

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