A novel SHIP1-selective inhibitor to induce blood cell recovery and stem cell engraftment
A32 is a highly selective small molecule that inhibits the SHIP1 enzyme, boosting blood cell growth factors and potentially improving recovery and immunity after chemotherapy, radiation, or stem cell transplantation, without affecting the related SHIP2 enzyme.
Background:
Hematopoiesis, the process by which blood cells are formed, is critical for...
Published: 6/29/2026
|
Inventor(s): William Kerr, Chiara Pedicone, Denzil Bernard
Keywords(s): bleeding disorders, Blood cell recovery, fungal infection, neutrophils, platelets, stem cell transplants, Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
|
Small molecule inhibition of SHIP1 induces broad activation of natural killer cells
This technology involves methods to activate natural killer (NK) cells by inhibiting the SHIP1 enzyme, offering new therapeutic approaches to treat cancers and infectious diseases.
Background:
Natural killer (NK) cells play a vital role in the body's innate immune defense, targeting and eliminating tumor cells and infected cells. However, their...
Published: 6/15/2026
|
Inventor(s): William Kerr, Matthew Gumbleton
Keywords(s):
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
|
Discovery of Novel SHIP1 Agonists
A new class of SHIP1 agonists that offer the potential for the development of new treatments for a variety of diseases.
Background:
An agonist is a drug or substance that binds to a cell receptor, producing the same action as the substance that would naturally bind to the receptor. Agonists form the basis for a wide variety of therapeutics. The...
Published: 3/18/2026
|
Inventor(s): William Kerr, Robert Anderson, John Chisholm, Sandra Denney, Shea Meyer, Angela Pacherille
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Artificial Intelligence, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare
|
Small Molecule Inhibitors for Alzheimer's Immunotherapy
Pan-SHIP1/2 inhibitors enhance phagocytosis of dead neurons and amyloid beta by microglia. Background: The beta-amyloid (1-42) peptide fragment is a crucial component of beta-amyloid debris that forms plaques in Alzheimer's Disease, playing a significant role in disease pathology and cognitive decline. Increased amyloid deposits and tau tangles...
Published: 1/30/2026
|
Inventor(s): William Kerr, Chiara Pedicone
Keywords(s): TAF, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
|
Biomarker Diagnostic for Crohn's Disease Severity
A novel messenger RNA transcript for prediction of ulcerative colitis and Crohn's disease severity. Background: More than 2 million individuals are diagnosed with Crohn's Disease (CD) and Ulcerative Colitis (UC) in the US every year. While much progress has been made in understanding these diseases, the causes are not fully known and effective...
Published: 1/30/2026
|
Inventor(s): William Kerr, Frank Middleton, Sandra Denney
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Campus > Upstate Medical University
|