Targeted Legumain-Cleavable Top1i ADC Platform
Tech Briefs: RSS Drafter said:
This technology introduces a legumain-cleavable antibody drug complex (ADC) that delivers topoisomerase inhibitors directly into tumor cells using a short, polar linker design. The platform employs low-potency Top1i derivatives that maintain strong in vivo efficacy while potentially improving safety, offering a balanced...
Published: 12/10/2025
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Inventor(s): Lawrence Tumey, Nicholas Bianchi, Victor Ojo
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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Optical Differential Microphone
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Published: 12/5/2025
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Inventor(s): Ronald Miles, F. Degertekin
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Electronics, Campus > Binghamton University
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Integrated Three-Core Nanocrystalline Planar Magnetics for Ultra-Efficient Power Conversion
This innovation integrates transformer and resonant inductors into a single nanocrystalline three-core planar structure for high-frequency CLLC resonant converters. By eliminating discrete magnetics and enabling precise inductance control with reduced losses, it delivers high power density, compact form factor, and exceptional efficiency for next-generation...
Published: 12/3/2025
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Inventor(s): Sunil Dube, Kalyan Yenduri, Pritam Das
Keywords(s): CleanTech, Technologies
Category(s): Campus > Binghamton University, Technology Classifications > Engineering
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Hydrophilic Asn-Asn-Linker Adcs for Potent and Stable Targeted Immunotherapy
This invention introduces hydrophilic TLR7 agonist antibody drug conjugates using a short Asn Asn linker that improves solubility, stability, and pharmacokinetics. By enabling precise site specific conjugation with reduced aggregation and strong innate immune activation, the platform delivers potent antitumor responses across multiple solid tumor indications.
Background:...
Published: 12/9/2025
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Inventor(s): Lawrence Tumey, Mohan Mullapudi
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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Dual Payload Antibody Conjugates for Combined Cytotoxic and Immune Stimulatory Cancer Therapy
This invention introduces a dual payload antibody drug conjugate platform that delivers both a potent cytotoxic agent and a TLR7 agonist to tumors with controlled, site specific attachment. By uniting targeted cell killing with localized immune activation in a single biologic, the approach improves therapeutic index, overcomes resistance, and enhances...
Published: 12/9/2025
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Inventor(s): Lawrence Tumey, Victor Ojo
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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Enzymatic Bioluminescent Beacons for Ultra-Sensitive, Rapid Nucleic Acid Detection
This invention introduces enzymatic bioluminescent beacons that generate bright, low-background light only upon binding their target sequence. A site-specific ligation strategy forms uniform 1 to 1 nanoluciferase–hairpin conjugates, enabling rapid, picomolar sensitivity detection with precise single-base discrimination in streamlined, equipment-light...
Published: 11/14/2025
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Inventor(s): Brian Callahan
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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Self-restructuring platinum ternary nanoalloys for durable low temperature exhaust oxidation
This invention introduces self-restructuring platinum-based ternary nanoalloy catalysts that maintain high oxidation activity after hydrothermal aging. By alloying Pt with two transition metals, the catalyst delivers durable low-temperature exhaust oxidation with reduced precious metal use, supporting efficient CO, hydrocarbon, and NO oxidation for...
Published: 11/12/2025
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Inventor(s): Chuan Jian Zhong, Shiyao Shan, Shan Wang
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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Ultra-compact Single-stage 48 V-to-Sub-1 V Converter with Adaptive Soft-switch Control
This invention presents a single-stage half-bridge converter that efficiently converts 48 V to sub-1 V using adaptive soft-switching control. By combining quasi-peak cycle-by-cycle current regulation with sensorless droop control, it achieves high efficiency, compact design, and rapid transient response for next-generation data-center, telecom, and...
Published: 11/12/2025
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Inventor(s): Tuhin Sasmal, Pritam Das
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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Room-Temperature Silver-Copper Nanoalloy Inks for Low-Cost Flexible Electronics
This invention introduces silver-copper (AgCu) nanoalloy inks and pastes that sinter at room temperature, enabling low-cost, flexible, and energy-efficient printed electronics. The formulation maintains high conductivity, resists oxidation, and can be printed on heat-sensitive substrates like paper, polymers, and textiles without external heating, supporting...
Published: 11/12/2025
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Inventor(s): Chuan Jian Zhong, Richard Robinson, Shan Wang, Shan Yan, Guojun Shang
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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Advanced Matrix Transformer Architecture for High-Efficiency 48V-to-Sub-1V Power Conversion
This invention introduces an advanced four-pillar matrix transformer architecture that doubles magnetizing inductance, reduces core volume, and minimizes circulating currents for compact, high-efficiency 48 V-to-sub-1 V conversion. Its optimized diagonal core geometry and parallel winding design improve thermal balance and efficiency, enabling scalable...
Published: 11/12/2025
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Inventor(s): Tuhin Sasmal, Pritam Das
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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