Development of novel liver-targeting glucocorticoid prodrugs
This technology presents novel liver-targeting glucocorticoid prodrugs designed to improve the treatment of inflammatory liver diseases and sepsis with enhanced efficacy and reduced systemic side effects.
Background:
Inflammatory liver diseases and sepsis represent significant clinical challenges due to their complex immune responses and the difficulty...
Published: 6/12/2026
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Inventor(s): Hong Lu, Juntao Luo, Dandan Guo
Keywords(s): glucocorticoid, inflammatory liver disease, liver-selective, nanoparticle, prodrug, sepsis, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
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A novel synthetic constitutive-active glucocorticoid receptor
Introducing "superGR," a novel synthetic glucocorticoid receptor fusion protein designed to enhance glucocorticoid therapy by providing ligand-independent activation and improved gene regulation for inflammatory diseases.
Background:
Glucocorticoids are widely used to treat inflammatory conditions like severe alcoholic hepatitis and sepsis, but their...
Published: 3/9/2026
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Inventor(s): Hong Lu, Conor Fahy
Keywords(s): gene therapy, glucocorticoid, inflammatory liver disease, lung injury, sepsis, synthetic materials, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
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Overcoming Short Channel Barrier Effects of Field Effect Transistors
A design tool for overcoming short channel barrier effects of field effect transistors (FET).
Background:
The semiconductor industry constantly pushes innovation, demanding research and development into new materials, manufacturing processes, and designs. Silicon is the most widely used semiconductor material in the electronic industry, so there...
Published: 6/19/2026
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Inventor(s): Hong Luo, Piaohan Xu
Keywords(s): Computer, Featured, General Engineering, Instrumentation, Semiconductor and Microprocessing, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Computers, Technology Classifications > Engineering, Technology Classifications > Instrumentation, Technology Classifications > Semiconductor Devices and Manufacturing
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Quantization in Gate-All-Around Field Effect Transistors
A design for quantization of electron states in the channel of gate-all-around field-effect transistors (GAAFET).
Background:
The semiconductor industry constantly pushes innovation, demanding research and development into new materials, manufacturing processes, and designs. Silicon is the most widely used semiconductor material in the electronic...
Published: 6/19/2026
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Inventor(s): Hong Luo, Piaohan Xu
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Bioinformatics, Technology Classifications > Computers, Technology Classifications > Electronics, Technology Classifications > Energy, Technology Classifications > Instrumentation, Technology Classifications > Nanotechnology
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