Utilize lipid nanoparticle-based CRISPR/Cas9 genome editing to delete the Pfkp gene for the treatment of head and neck cancer
This technology introduces a novel lipid nanoparticle-based CRISPR/Cas9 system designed to target the Pfkp gene for the effective treatment of head and neck cancer.
Background:
Head and neck cancer continues to pose a significant clinical challenge due to its aggressive nature and poor patient prognosis. A primary contributing factor is the overexpression...
Published: 6/22/2026
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Inventor(s): Yamin Li
Keywords(s): cancer, cancer therapy, lipids, nanoparticle, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics and Vaccines
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Targeting Protein Phosphatase-5 in Cancer
This technology introduces a novel approach to cancer treatment by targeting Protein Phosphatase 5 (PP5) to regulate apoptosis and inhibit tumor growth, particularly in clear cell renal cell carcinoma (ccRCC).
Background:
Cancer cells often evade programmed cell death, allowing tumors to grow unchecked. In clear cell renal cell carcinoma, dysregulation...
Published: 6/22/2026
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Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, John Chisholm, Dimitra Bourboulia, Mark Woodford
Keywords(s): cancer, cancer therapy, phosphorylation, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy
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Raman Spectroscopy for Probing Encapsulation of mRNA in Lipid Nanoparticles
This technology uses deep ultraviolet Raman spectroscopy and advanced data analysis to quickly and non-destructively measure how much mRNA is unencapsulated in lipid nanoparticles, improving quality control for mRNA vaccines and therapeutics without chemical labels.
Background:
Messenger RNA (mRNA) therapeutics, particularly those delivered via lipid...
Published: 6/12/2026
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Inventor(s): Igor Lednev, Alexander Shekhtman, Sergei Reverdatto, Sila Jin, Young Mee Jung
Keywords(s): mRNA, Raman spectroscopy, spectroscopy, statistical analysis, Technologies, therapeutics, vaccines
Category(s): Campus > University at Albany, Technology Classifications > Gene Therapy
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Temporal Control of CRISPR-Cas9 using Bio-orthogonal Chemistry.
This technology enables precise, time-controlled activation or deactivation of CRISPR-Cas9 genome editing using biocompatible chemical reactions, reducing off-target effects and improving the safety and accuracy of gene editing for research and therapeutic applications.
Background:
Genome editing technologies, particularly CRISPR-Cas9, have revolutionized...
Published: 5/5/2026
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Inventor(s): Maksim Royzen, Bhoomika Pandit
Keywords(s): biochemistry, CRISPR, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Gene Therapy
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Virus-Like Particles for mRNA Delivery
Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs.
Background:
Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...
Published: 6/19/2026
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Inventor(s): Sriram Neelamegham, Qi Yang
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Gene Therapy, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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