PI 3-Kinase Cancer Immunotherapy
Pancreatic cancer patients will be treated with a PI3K inhibitor to induce the cancer cells to reveal their antigens to the immune system Background: Standard chemotherapies have little impact on pancreatic cancer (PDAC) patient survival, and new T-cell therapies have yet to be successful in treating solid tumors. Phosphoinositide 3-kinase (PI3K),...
Published: 2/29/2024
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Inventor(s): Richard Lin
Keywords(s): cancer, immunotherapy, phosphoinositide 3-kinase (PI3K), PI3K inhibitors, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Gene Therapy and Viral Vectors, Technology Classifications > Therapeutics
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Novel Bioabsorbable Membranes for Cell Delivery Applications
Methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system. Background: Methods and compositions for encapsulating core materials, e.g., materials containing drugs, have been disclosed. These methods generally involve encapsulating the core material within a micro capsule by forming...
Published: 11/22/2023
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Inventor(s): Benjamin Chu, Benjamin Hsiao, Michael Hadjiargyrou, Dufei Fang, Xinhua Zong, KwangSok Kim
Keywords(s):
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Gene Therapy and Viral Vectors
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Single Chain Antibody (Mab69) Against the NG2 Proteoglycan
AAV based viral vectors that express either AAV-NG2Ab or AAV-NT3 have been shown to provide improved recovery of motor function in models. Background: Spinal Cord Injury (SCI) affects nearly 270,000 Americans and is a common cause of permanent disability and death in children and adults. Despite being a significant burden to the patients, society...
Published: 9/4/2024
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Inventor(s): Joel Levine, Victor Arvanian
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Gene Therapy and Viral Vectors, Technology Classifications > Therapeutics
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Genetically Engineered AAV Rep for Gene Targeting and rAAV Production
Researchers at Stony Brook University have identified a genetic element within the Rep gene sequence which is inhibitory to Ad replication. Background: Gene therapy strategies have exploited lenti or retro viral approaches for long-term gene replacement, however, their clinical applications remain limited because of potential for viral-associated...
Published: 9/9/2024
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Inventor(s): Wadie Bahou, Patrick Hearing, Varsha Sitaraman
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Gene Therapy and Viral Vectors, Technology Classifications > Therapeutics, Technology Classifications > Research Tools and Reagents
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