Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy
050-9150 Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy
A unique immunotherapy paradigm to treat castrate-resistant prostate cancer and its metastatic form
RSS.HDBackground> Background: <
Prostate cancer is one of the leading causes of cancer death, with 1 in 10 men diagnosed in their lifetime and 1 in 41 dying from the...
Published: 8/24/2023
|
Inventor(s): Labros Meimetis, Eszter Boros
Keywords(s): Technologies
Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics, Campus > Stony Brook University
|
Chemically Modified Curcumins (CMCs) Their Homologues and Lower Analogues as Inhibitors of Matrix Metalloproteases (MMPs) and Pro-inflammatory Cytokines (PICs)
Novel class of compound that display biological activities equal to or better than natural curcumin, which has been used throughout history to treat a wide variety of ailments. Background: Curcumin, a principal biological compound in the popular Indian curry spice turmeric, has been used throughout history to treat a wide variety of skin, pulmonary,...
Published: 11/22/2023
|
Inventor(s): Lorne Golub
Keywords(s): Medical, Technologies
Category(s): Technology Classifications > Therapeutics
|
PI 3-Kinase Cancer Immunotherapy
Pancreatic cancer patients will be treated with a PI3K inhibitor to induce the cancer cells to reveal their antigens to the immune system Background: Standard chemotherapies have little impact on pancreatic cancer (PDAC) patient survival, and new T-cell therapies have yet to be successful in treating solid tumors. Phosphoinositide 3-kinase (PI3K),...
Published: 2/29/2024
|
Inventor(s): Richard Lin
Keywords(s): cancer, immunotherapy, phosphoinositide 3-kinase (PI3K), PI3K inhibitors, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Gene Therapy and Viral Vectors, Technology Classifications > Therapeutics
|
Method of Treating Alzheimer's Disease with X-ray Minibeams
An x-ray therapy method for treating Alzheimer's disease that maintains a tissue-sparing effect allowing for higher doses Background: Alzheimer?s Disease is the most common form of dementia among the elderly and affects over five million individuals in the United States. To date, there is no definitive treatment to cure or halt the progression...
Published: 11/22/2023
|
Inventor(s): Avraham Dilmanian, Renee Cattell, Lev Bangiyev
Keywords(s): cell differentiation, computed tomography (CT) scanner, glial progenitor cells, radiation therapy, Technologies, tissue-sparing effect, x-ray microbeams
Category(s): Campus > Stony Brook University, Technology Classifications > Medical Devices, Technology Classifications > Therapeutics
|
Novel Prodrugs for Selective Anticancer Therapy
Novel methods to make anticancer prodrugs by conjugating unique dual-substrate biochemical modules to known or novel chemotherapeutic drugs Background: Anticancer drug sales exceeded $50 billion worldwide in 2009 with impressive growth; however, lack of target selectivity is a major challenge in cancer treatment. The limitation of current chemotherapy...
Published: 11/22/2023
|
Inventor(s): Michael Hayman, Nobuhide Ueki
Keywords(s): anticancer drugs, cancer-associated protease, HDAC, nucleoside analogues, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Therapeutics
|
Crosslinked Thermoreversible Pluronic Hydrogels for Prosthetic Disc Nucleus Replacement
An easily injectable crosslinked hyaluronic acid-gelatin hydrogel that can be used as a prosthetic replacement for a spinal disc nucleus Background: When a spinal disc becomes damaged due to trauma or disease resulting in a disc herniation, it may become necessary to replace a natural spinal disc nucleus with a prosthesis. Such prostheses should preferably...
Published: 11/22/2023
|
Inventor(s): Miriam Rafailovich, Raphael Davis, Divya Bhatnagar
Keywords(s): Gelatin, Hyaluronic Acid, Hydrogels, Pluronic, Spinal Disc, Technologies, thermoreversible
Category(s): Campus > Stony Brook University, Technology Classifications > Medical Devices, Technology Classifications > Material and Composites, Technology Classifications > Therapeutics
|
Enhancing Responses to Chemical Interventions by Programmed Introduction of Multiple Refractory Periods
A medical device that can deliver multiple, brief intervention doses over a 24 hour period that improves cell biologic responses. Background: The ability of any exogenous intervention, be it physical or chemical in nature, to influence cell activity is markedly enhanced by incorporating a rest period between stimulation periods within any given...
Published: 6/5/2023
|
Inventor(s): Clinton Rubin
Keywords(s): Adaptation, Adipogenesis, Adult Stem Cells, Augmentation, Bioelectrical, Bioengineering, Biological, Biomechanical, Biomedical or Biotechnology, Device, Enhancement, Intervention, Mechanical, Mesenchymal Stem Cells, Non-invasive, Osteogenesis, Pharmaceutical, Repair, Stimulation, Technologies, Timing, Tissue
Category(s): Campus > Stony Brook University, Technology Classifications > Medical Devices, Technology Classifications > Therapeutics
|
Methods of Treating and Preventing Angioedema and Vascular Leakage
Peptides and antibodies that block vascular permeability induced in angioedema patients that are new targets for treatment. Background: Angioedema associated with C1-INH deficiency is an inherited or acquired condition that affects 20 per cent of the population. The condition can be disfiguring, painful and sometimes fatal. Existing treatments primarily...
Published: 11/22/2023
|
Inventor(s): Berhane Ghebrehiwet
Keywords(s): angioedema, gClqR, Medical, Monoclonal antibody, peptides, Technologies, vascular leakage
Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Therapeutics
|
Enzymatic Capsulotomy for Shoulder Adhesive Capsulitis
A minimally invasive collagenase injection method for treating frozen shoulder that is cost-effective Background: Adhesive capsulitis of the shoulder, more commonly known as frozen shoulder, results in painful limitation of shoulder motion. It can arise idiopathically or after trauma. The current standard of care is a long course of painful physical...
Published: 11/22/2023
|
Inventor(s): Marie Badalamente, Edward Wang
Keywords(s): Collagenase Injection, Frozen shoulder, Nonoperative Therapy, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Therapeutics
|
Novel Method For Enzymatic Production of Cyclic-diGMP
Enzymes for synthesizing large quantities of cyclic-diGMP that are low cost and retain enzymatic activity for several months Background: Cyclic bis (3?,5?) diguanylate monophosphate or (cyclic-diGMP) is a bacterial secondary messenger involved in the regulation of various cellular processes that have medical and agricultural implications including...
Published: 2/28/2024
|
Inventor(s): Elizabeth Boon, Natasha Nesbitt, Roger Johnson
Keywords(s): c-di-GMP, cyclic diguanylate monophosphate, diguanylate cyclase, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Therapeutics, Technology Classifications > Research Tools and Reagents
|