Detection of Biomolecule Carbonylation
Measuring oxidative stress in living systems is a critical challenge—current detection methods rely on unstable ROS markers or harsh chemical assays that damage cells and prevent real-time analysis. This invention introduces biocompatible fluorescent probes that directly detect oxidative stress–induced carbonylation in live cells and tissues,...
Published: 4/28/2026
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Inventor(s): Susan Tuttle, Kamalika Mukherjee
Keywords(s):
Category(s): Campus > Binghamton University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Materials and Chemicals
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Natural Enamel
A method to produce natural enamel that minimizes microleakage with better esthetic acceptance Background: CAD/CAM (Computer-Aided Design and Computer-Aided Manufacturing) technology in dentistry provides a range of dental restorations including crowns, veneers, inlays and onlays, fixed bridges and dental implant restorations. The materials...
Published: 7/25/2025
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Inventor(s): Stephanos Kyrkanides, Li Ma, Sabine Brouxhon
Keywords(s): CAD/CAM, enamel, restoration, Technologies, tooth
Category(s): Campus > Stony Brook University, Technology Classifications > Healthcare IT, Technology Classifications > Information Technology, Technology Classifications > Medical Devices
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A New Bioorthogonal Reaction
This technology enables extremely fast and stable bioconjugation using a unique boron–nitrogen bond-forming reaction. It works efficiently in water at neutral pH, avoiding harsh conditions required by many existing methods. The approach delivers rapid, clean, and reliable coupling for sensitive biological systems, supporting fast labeling workflows...
Published: 5/1/2026
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Inventor(s): Susan Bane Tuttle, Özlem Dilek, Kamalika Mukherjee
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Antibodies, Campus > Binghamton University
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Inhibition of the Soluble Extracellular Domain of E-cadherin: A Novel Tumoricidal Drug for Cancers
Monoclonal antibodies that have demonstrated profound antitumor effects both in vitro and in vivo. Background: Over the last decade, the most significant revolutionary advances in oncology have been the introduction and FDA approval of targeted monoclonal antibodies (mAb) against the human epidermal growth factor receptor (HER1-4) family. In combination...
Published: 8/29/2025
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Inventor(s): Sabine Brouxhon, Stephanos Kyrkanides, Marcia Simon, Li Ma, Liqun Wang, Soosan Ghazizadeh
Keywords(s): TAF, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications, Technology Classifications > Therapeutics and Vaccines
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