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Detection of Biomolecule Carbonylation

Rapid, accurate, and biocompatible oxidative damage detection probe Background: Oxidative stress is a characteristic of many disease states. One result of oxidative stress is an irreversible reaction of radicals with biomolecules that results in covalent addition of carbonyls to the biomolecules. The presence, location and amount of carbonylation...
Published: 12/28/2023   |   Inventor(s): Susan Tuttle, Kamalika Mukherjee
Category(s): Campus > Binghamton University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Materials and Chemicals

Natural Enamel

A method to produce natural enamel that minimizes microleakage with better esthetic acceptance Background: CAD/CAM (Computer-Aided Design and Computer-Aided Manufacturing) technology in dentistry provides a range of dental restorations including crowns, veneers, inlays and onlays, fixed bridges and dental implant restorations. The materials...
Published: 11/22/2023   |   Inventor(s): Stephanos Kyrkanides, Li Ma, Sabine Brouxhon
Keywords(s): CAD/CAM, enamel, restoration, Technologies, tooth
Category(s): Campus > Stony Brook University, Technology Classifications > Healthcare IT, Technology Classifications > Information Technology, Technology Classifications > Material and Composites, Technology Classifications > Medical Devices

Labeling Microtubes in Live Cells

A technique that allows live visualization of microtubules without genetic manipulation or perturbing protein function Background: Microtubules are a fundamental component of the cytoskeleton of eukaryotic cells, and the observation of microtubule dynamics in live cells using fluorescence microscopy is of critical importance in studying cytoskeleton...
Published: 12/29/2023   |   Inventor(s): Susan Bane Tuttle, Kamalika Mukherjee
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Imaging, Campus > Binghamton University

A New Bioorthogonal Reaction

A fast, stable, versatile biomolecule coupling technology based on a bioorthogonal reaction that can occur at neutral pH and room temperature Background: “Click Chemistry” reactions are high yielding, wide in scope, create only byproducts that can be removed without chromatography, simple to perform, and can be conducted in easily removable...
Published: 7/13/2022   |   Inventor(s): Susan Bane Tuttle, Özlem Dilek, Kamalika Mukherjee
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Antibodies, Campus > Binghamton University

Inhibition of the Soluble Extracellular Domain of E-cadherin: A Novel Tumoricidal Drug for Cancers

Monoclonal antibodies that have demonstrated profound antitumor effects both in vitro and in vivo. Background: Over the last decade, the most significant revolutionary advances in oncology have been the introduction and FDA approval of targeted monoclonal antibodies (mAb) against the human epidermal growth factor receptor (HER1-4) family. In combination...
Published: 11/22/2023   |   Inventor(s): Sabine Brouxhon, Stephanos Kyrkanides, Marcia Simon, Li Ma, Liqun Wang, Soosan Ghazizadeh
Keywords(s): TAF, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Therapeutics

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