Taxane anticancer agents, their pharmaceutical compositions and their use
050-9465 Taxane anticancer agents, their pharmaceutical compositions and their use
New taxane anticancer compounds designed with carbamate substituents at the C-10 position with lower cytotoxicity and superior potency
Background:
Despite advances in chemotherapeutic interventions, cancer remains the second largest cause of death in the United States....
Published: 5/7/2026
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Inventor(s): Iwao Ojima, Hersh Bendale, Kalani Jayanetti, Ananya Shibana Thennarasu
Keywords(s):
Category(s): Technology Classifications > Drug Design and Synthesis, Campus > Stony Brook University
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Structurally and Functionally Diverse Heterocyclic Dipeptide Isosteres and Their Derivatives as Antimicrobial Agents and Peptidomimetic Building Blocks
This technology enables rapid, modular synthesis of diverse heterocyclic dipeptide isosteres with potent antimicrobial activity, which can be easily incorporated into peptides to create stable, bioactive molecules for drug discovery and therapeutic applications.
Background:
The field of antimicrobial drug discovery and peptidomimetic development...
Published: 5/5/2026
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Inventor(s): Sujit Suwal, Olga Novikova
Keywords(s): antibacterial, Bioactive heterocyclic amino esters and peptidomimetics, Chemo-selective synthesis of heterocyclic amino esters, iterative Buchwald Hartwig amination and Suzuki coupling, Technologies
Category(s): Campus > Buffalo State College, Technology Classifications > Drug Design and Synthesis
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Apelin-Receptor (APJ) Antagonists
A series of stable, small molecule compounds that inhibit an alternative (non-VEGF) angiogenic pathway that is overexpressed in a variety of cancers.
Background:
Antiangiogenic drugs targeting the vascular endothelial growth factor (VEGF) signaling pathway are widely used to treat solid tumors and ocular conditions such as wet AMD. However, anti-VEGF...
Published: 4/16/2026
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Inventor(s): Youngjae You, Sukyung Woo, Ganesh Bist, Ahmed Elsheikh
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Drug Design and Synthesis
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Methods for detecting RNA modifications with DNA nanoswitches
This technology uses DNA nanoswitches to directly and specifically detect RNA modifications, allowing simultaneous identification of multiple modifications in their natural sequence context for research, diagnostics, and drug discovery applications.
Background:
RNA modifications, such as methylation, play critical roles in gene regulation, cellular...
Published: 3/26/2026
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Inventor(s): Kenneth Halvorsen, Iranna Todkari, Andrew Hayden
Keywords(s): DNA nanoswitches, RNA modifications, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Design and Synthesis
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Development of SelU Inhibitors as New Antibiotics
Scientists discovered that special chemical modifications on bacterial tRNA help control protein production and stress responses. They have also developed novel compounds that take advantage of this mechanism to produce antibiotic effects.
Background:
The field of epitranscriptomics focuses on the chemical modifications of RNA molecules, which are...
Published: 3/5/2026
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Inventor(s): Jia Sheng, Thomas Begley
Keywords(s): antibiotics, inhibitors, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Drug Design and Synthesis
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Sterylglucosidase Inhibitors as Antifungal Agents
050-9346 Sterylglucosidase Inhibitors as Antifungal Agents
Novel antifungal compounds that function as substrate-mimicking inhibitors of sterylglucosidase for antifungal medication and therapeutics
Background:
Invasive fungal infections, such as life-threatening meningoencephalitis caused by Cryptococcus neoformans and severe pulmonary aspergillosis...
Published: 5/4/2026
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Inventor(s): Iwao Ojima, Maurizio Del Poeta, Michael Airola, Nivea Pereira de Sa, SeungYoun Shin, Kalani Jayanetti, Dominick Rendina, Ananya Shibana Thennarasu
Keywords(s):
Category(s): Technology Classifications > Drug Design and Synthesis, Campus > Stony Brook University, Campus
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Macrocycle-Based Chelators for Room Temperature Chelation of Radioactive Isotopes
050-9235 Macrocycle-Based Chelators for Room Temperature Chelation of Radioactive Isotopes
Ternary complexes that produce robust radiopharmaceuticals with a high radiochemical yield and specific activity for enhanced radiolabeling
Background:
The management of various cancers, particularly prostate cancer, increasingly relies on targeted radiotherapeutics...
Published: 5/4/2026
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Inventor(s): Eszter Boros, Brett Vaughn, Jennifer Whetter
Keywords(s):
Category(s): Technology Classifications > Drug Design and Synthesis, Technology Classifications > Medical Imaging, Campus > Stony Brook University
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LpxC Inhibitors for Gram-Negative Infections
Treatment of multidrug-resistant bacterial infections with LpxC inhibitors for reduced drug resistance and improved safety profiles
RSS.HDBackground> Background: <
Infection by Gram‑negative bacteria such as Pseudomonas aeruginosa, β‑lactamase producing (ESBL) Enterobacteriaceae, and Acinetobacter baumannii is a major health problem, especially...
Published: 7/25/2025
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Inventor(s): Peter Tonge, Fereidoon Daryaee, Sneha Basak
Keywords(s):
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis
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Design and Synthesis of Novel Methotrexate Conjugated MicroRNA Mimic Modified with 5-Fluorouracil and/or Gemcitabine as a Platform Technology for Cancer Treatment
A platform for modifying miRNAs and using the modified miRNAs as novel cancer therapeutics.
RSS.HDBackground> Background: <
Resistance to chemotherapy can be a highly complex issue, with epigenetic alterations playing a key role in tumorigenesis and chemotherapy resistance. The failure to treat several advanced solid tumors can be often attributed...
Published: 7/25/2025
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Inventor(s): Jingfang Ju, Iwao Ojima, John Yuen, Lei Chen
Keywords(s):
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis
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Concerted, Selective Radiometallation and Photo-triggered Release of Ready-to-Inject Radiopharmaceuticals from the Solid Phase
Solid Phase Radiometallation Photorelease method for the preparation of injectable radiopharmaceuticals
RSS.HDBackground> Background: <
Radiopharmaceuticals are agents which enable non-invasive patient diagnosis and personalized therapeutic intervention strategies. Radionuclides used in nuclear medicine applications must be purified after nuclear...
Published: 2/4/2025
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Inventor(s): Eszter Boros, Dariusz Śmiłowicz
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis
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