Glycosyltransferase Mutation-Activity Landscape
A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases
Background:
Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...
Published: 9/12/2025
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Biotechnology, Diagnostic, Pharmaceutical, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering
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Machine Learning Diagnosis of In Vivo Tissues by Extracting Tissue-Energy Characteristic Features from Non-Invasively Acquired Computed Tomographic Data
The technology features enable ML models to more accurately classify indeterminate pulmonary nodules and colorectal polyps
Background:
Computed tomography (CT) is a widely used imaging tool for early detection of cancers such as lung and colorectal cancer. However, current low-dose CT screening protocols suffer from high false positive rates, particularly...
Published: 9/19/2025
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Inventor(s): Jerome Liang
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence, Technology Classifications > Computer Software, Technology Classifications > Diagnostics, Technology Classifications > Healthcare IT, Technology Classifications > Information Technology, Technology Classifications > Medical Imaging, Campus > Stony Brook University
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Dual isotope labeled Alanines as imaging agents for chronic diseases detection
Novel PET tracers for detecting chronic diseases with improved specificity for detecting bacterial infection
Background:
Positron emission tomography (PET) is a non-invasive, functional imaging technique that is used to monitor metabolic processes and diagnose diseases including cancer and bacterial infections. Fluorodeoxyglucose (FDG) is the most...
Published: 10/6/2025
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Inventor(s): Wenchao Qu, Kaixuan Li, Peter Tonge
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Imaging, Campus > Stony Brook University
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Enhanced Fluorophore Discrimination in Fluorescence Microscopy Using Multi View Spectral Unmixing with Photobleaching Dynamics
This technology allows researchers to more easily distinguish hundreds of fluorescent labels in a single image, useful for a wide variety of biological applications.
Background:
There are hundreds to thousands of different cells or other structures that can be labeled with fluorescent reporters in a biological sample, and then imaged on a fluorescence...
Published: 9/11/2025
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Inventor(s): Alex Valm, Yunlong Feng, Ruogu Wang
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Bioinformatics, Technology Classifications > Artificial Intelligence, Technology Classifications > Imaging, Technology Classifications > Optics and Photonics, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Healthcare, Technology Classifications > Diagnostics, Technology Classifications > Dental
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Method and Apparatus for Simultaneous Acquisition of Electrocardiogram Signals and Electrical Impedance Tomography Data
A new imaging technology that can be used with an electrocardiogram to aid the diagnosis and treatment of cardiac and pulmonary conditions.
Background:
Electrical impedance tomography (EIT) is a new imaging technology that can be used with an electrocardiogram (EKG) to aid the diagnosis and treatment of cardiac and pulmonary conditions. Examples...
Published: 5/13/2025
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Inventor(s): Gary Saulnier, Ahmed Abdelwahab, Omid Rajabi Shishvan, Nilton Barbosa da Rosa
Keywords(s): electrical impedance tomography, electrocardiogram, heart/lung function, medical equipment, medical imaging, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging
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In Vitro Dental Plaque Culture Model for Biofilm Structural Analyses
This technology provides a valuable tool for studying the molecular and cellular basis of dental plaque-mediated diseases.
Background:
In vitro oral microcosm communities, seeded with mixed communities of human dental plaque, have proven to be essential tools for studying the taxonomic composition of dental plaque communities and changes in community...
Published: 5/13/2025
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Inventor(s): Alex Valm
Keywords(s): biofilm control, dental, dental materials, structural biology, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Dental, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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Luminescent Biosensor for Detection of Specific Nucleotide Sequences, Small Molecules, and Proteins at Point-of-Care
A serotonin release assay that requires no special training or expensive equipment, and produces results within hours. Background:
Platelet serotonin release assay (SRA) is a widely-used clinical assay for diagnosing heparin-induced thrombocytopenia (HIT), a life-threatening complication of heparin treatment. The current SRA procedure entails sending...
Published: 5/13/2025
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Inventor(s): Stewart Loh, Harsimranjit Sekhon
Keywords(s): biomarker diagnostics, biosensor, detection, DNA nanoswitches, protein engineering, sensor, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines
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Laser Ablation Direct Analysis in Real Time-Imaging Mass Spectrometry (LADI-MS)
Offers the potential of real-time small-sample analysis for a very large variety of applications.
Background:
Real Time Imaging Mass Spectrometry (RTMS) is a method for analyzing and identifying biological samples in real time. RTMS can be used in an extremely broad variety of applications, involving chemistry, biochemistry, food sciences, and medicine....
Published: 6/26/2025
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Inventor(s): Rabi Musah
Keywords(s): analytical chemistry, Biomarker discovery, chemistry, forensic testing, image acquisition, imaging, life sciences, Mass spectrometry imaging, medical imaging, Natural products, Phytochemistry, Small-molecule profiling, Small-molecule spatial distribution mapping, Species discrimination, Species identification, Technologies, Tissue analysis, wood anatomy, wood science
Category(s): Campus > University at Albany, Technology Classifications > Agriculture, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Drug Delivery, Technology Classifications > Environment, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Imaging, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents
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Novel, Reliable and Rapid Diagnostic Test for TBI
An effective, reliable and rapid diagnostic test to determine traumatic brain injury with the aid of a laptop. Background: Mild traumatic brain injury (TBI) is often followed by acute cognitive impairments. These differ in type, severity and persistence. Most patients recover, but about 20% progress to post-concussive syndrome (PCS), and a long-lasting...
Published: 5/13/2025
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Inventor(s): Peter Bergold, William Lytton, Yosef Skolnick
Keywords(s): cerebral hemisphere, crossed and uncrossed reaction time, reaction speed, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Diagnostics
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Stratification Method that Determines the Prognosis of Breast Cancer at a Personalized Level
A reliable, accurate, and versatile method for determining the prognosis of primary breast cancer tumors post-surgery.
Background:
Breast cancer is the second most common type of cancer in women in the United States, after skin cancer. On rare occasions, it can also occur in men. According to the American Cancer Society, nearly 300,000 new cases...
Published: 5/13/2025
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Inventor(s): Vladimir Kuznetsov, Leszek Kotula
Keywords(s): biomarkers, biostatistics, breast cancer, diagnostics, functional genomics, gene expression analysis, oncology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Medical Devices
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