Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 11/20/2024
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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In Vitro Dental Plaque Culture Model for Biofilm Structural Analyses
This technology provides a valuable tool for studying the molecular and cellular basis of dental plaque-mediated diseases.
Background:
In vitro oral microcosm communities, seeded with mixed communities of human dental plaque, have proven to be essential tools for studying the taxonomic composition of dental plaque communities and changes in community...
Published: 10/3/2024
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Inventor(s): Alex Valm
Keywords(s): biofilm control, dental, dental materials, structural biology, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Dental, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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AI-Optimized Spectral CT Reconstruction for Improved Lesion Imaging and Diagnosis
System that uses an AI algorithm to enhance tissue-specific textures in spectral CT images and identify benign and malignant tumors
RSS.HDBackground> Background: <
Spectral CT is an imaging modality that allows for tissue‑specific texture differentiation, along with anatomical information provided by conventional CT. However, current methods...
Published: 9/17/2024
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Inventor(s): Jerome Liang, Yongyi Shi, Yongfeng Gao
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence, Technology Classifications > Diagnostics, Technology Classifications > Computer Software, Technology Classifications > Healthcare IT, Technology Classifications > Information Technology, Technology Classifications > Medical Imaging, Campus > Stony Brook University
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Arterial Carbon Dioxide Monitoring Device
A low-cost device for non-invasive, efficient, accurate, and quick detection of ventilatory changes in medical patientsRSS.HDBackground> Background: <Many medical environments and conditions require the measurement of arterial carbon dioxide (CO2) in non‑invasive ways. Opioids, for example, impair breathing by suppressing the excitability of neurons...
Published: 6/21/2024
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Inventor(s): Yosman Dhar, Christopher Page
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Sensors, Technology Classifications > Wireless Technology, Campus > Stony Brook University
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Positron Emission Tomography (PET) Radiotracer
Composition, method and diagnostic use of positron imaging tomography imaging agent for bacterial infection detectionRSS.HDBackground> Background: <Positron emission tomography (PET) radiotracer is a diagnostic tool to detect bacterial infection in humans. A deficiency exists in clinical diagnostic tools capable of identifying bacterial infections...
Published: 2/1/2024
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Inventor(s): Peter Tonge, Yong Li, Fereidoon Daryaee, Peter Smith-Jones, Labros Meimetis
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents, Campus, Campus > Stony Brook University
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Nucleic Acids that Encode Sodium Channels
Provides a method for screening compounds for use as anti-arrhythmic agents and other medications using mutant mammalian voltage-gated sodium channel subunit.
Background:
Mammalian voltage-gated sodium channels are pore-forming membrane proteins responsible for the initiation and propagation of actions in nerve, skeletal muscle, and heart cells. The...
Published: 1/29/2024
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Inventor(s): Sho-Ya Wang
Keywords(s):
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Technology Classifications > Drug Delivery
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Laser Ablation Direct Analysis in Real Time-Imaging Mass Spectrometry (LADI-MS)
Offers the potential of real-time small-sample analysis for a very large variety of applications.
Background:
Real Time Imaging Mass Spectrometry (RTMS) is a method for analyzing and identifying biological samples in real time. RTMS can be used in an extremely broad variety of applications, involving chemistry, biochemistry, food sciences, and medicine....
Published: 1/23/2024
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Inventor(s): Rabi Musah
Keywords(s): analytical chemistry, Biomarker discovery, chemistry, forensic testing, image acquisition, imaging, life sciences, Mass spectrometry imaging, medical imaging, Natural products, Phytochemistry, Small-molecule profiling, Small-molecule spatial distribution mapping, Species discrimination, Species identification, Technologies, Tissue analysis, wood anatomy, wood science
Category(s): Campus > University at Albany, Technology Classifications > Agriculture, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Drug Delivery, Technology Classifications > Environment, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Imaging, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents
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Stable Micelle Drug Formulations
Method for producing stable, concentrated drug micelles that reduce or eliminate surfactants from drug formulations.
Background:
Hydrophobic drugs comprise a substantial proportion of all pharmaceutical compounds in use today. These drugs have limited solubility in water. There are numerous strategies for addressing solubility; however, for many...
Published: 5/23/2024
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Inventor(s): Jonathan Lovell, Wentao Song, Yumiao Zhang
Keywords(s): Technologies
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Drug Delivery, Technology Classifications > Nanotechnology, Campus > University at Buffalo
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Luminescent Biosensor for Detection of Specific Nucleotide Sequences, Small Molecules, and Proteins at Point-of-Care
A serotonin release assay that requires no special training or expensive equipment, and produces results within hours. Background:
Platelet serotonin release assay (SRA) is a widely-used clinical assay for diagnosing heparin-induced thrombocytopenia (HIT), a life-threatening complication of heparin treatment. The current SRA procedure entails sending...
Published: 4/3/2024
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Inventor(s): Stewart Loh, Harsimranjit Sekhon
Keywords(s): biomarker diagnostics, biosensor, detection, DNA nanoswitches, protein engineering, sensor, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines
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Novel, Reliable and Rapid Diagnostic Test for TBI
An effective, reliable and rapid diagnostic test to determine traumatic brain injury with the aid of a laptop. Background: Mild traumatic brain injury (TBI) is often followed by acute cognitive impairments. These differ in type, severity and persistence. Most patients recover, but about 20% progress to post-concussive syndrome (PCS), and a long-lasting...
Published: 7/11/2023
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Inventor(s): Peter Bergold, William Lytton, Yosef Skolnick
Keywords(s): cerebral hemisphere, crossed and uncrossed reaction time, reaction speed, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Diagnostics
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