Prodrug Nanoformulations of Amphotericin B conjugated Phenylboronic acid containing Telodendrimer Nanocarriers in Systemic Fungal Infections Treatment
This technology uses telodendrimer prodrugs combined with boronate chemistry to improve drug delivery and effectiveness.
Background:
The field of drug delivery has seen significant advancements over the past few decades, particularly in the development of targeted therapies that can improve the efficacy and safety profiles of pharmaceutical agents....
Published: 6/22/2026
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Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): Technologies
Category(s): Technology Classifications > Drug Delivery, Campus > Upstate Medical University
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Bioactive Telodendrimer Nanocarrier for Antibiotics Delivery and Immune Modulation
Novel telodendrimer nanoparticles have been developed to enhance the delivery and safety profile of the antibiotic Polymyxin B by improving its stability and reducing toxicity during treatment.
Background:
Polymyxin B (PMB) is a powerful antibiotic used to treat infections caused by Gram-negative bacteria, but its clinical application is limited...
Published: 6/12/2026
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Inventor(s): Juntao Luo, Dandan Guo, Md Shanewaz Hossan, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
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Pancreas-specific mRNA delivery enabled by sulfonium lipid nanoparticles
This technology presents a novel class of lipid nanoparticles engineered for targeted delivery of mRNA specifically to the pancreas following systemic administration.
Background:
Effective delivery of RNA therapeutics to specific organs remains a significant challenge in biomedical research. The pancreas, in particular, has been a difficult target...
Published: 6/12/2026
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Inventor(s): Yamin Li, Yuqin Men
Keywords(s): mRNA, nanoparticle-enhanced delivery, nanoparticles, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
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A lung-targeting britannin-lipid nanoparticle formulation and use thereof
This technology is a novel lung-targeting britannin-lipid nanoparticle formulation designed to effectively treat acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) by inhibiting lung inflammation.
Background:
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe lung conditions characterized by intense...
Published: 6/12/2026
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Inventor(s): Yamin Li, Qinghe Meng, Daping Fan
Keywords(s): acute lung injury, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
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Development of novel liver-targeting glucocorticoid prodrugs
This technology presents novel liver-targeting glucocorticoid prodrugs designed to improve the treatment of inflammatory liver diseases and sepsis with enhanced efficacy and reduced systemic side effects.
Background:
Inflammatory liver diseases and sepsis represent significant clinical challenges due to their complex immune responses and the difficulty...
Published: 6/12/2026
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Inventor(s): Hong Lu, Juntao Luo, Dandan Guo
Keywords(s): glucocorticoid, inflammatory liver disease, liver-selective, nanoparticle, prodrug, sepsis, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
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Chemical Modifications of Substrates Using Zwitterionic-Functionalized Dendrimers
Novel platform for biomaterials development with advanced physiological properties
BACKGROUND:
The need for improved biomaterials is a continuous challenge in the clinical field. Extended physiological circulation times, reduced immune responses, and lowered cytotoxicity are a few parameters crucial for therapeutic and diagnostic biomaterials. ...
Published: 6/19/2026
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Inventor(s): Chong Cheng, Mingxuan Zhang, Yun Wu, Ziwen Zhang
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Drug Delivery, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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Functionalized Dendrimers with Regioselective Reactivity
Novel compositions of zwitterionic dendrimers and derived polymers
BACKGROUND:
There is a strong need for new classes of reactive reagents for the generation of novel materials with pre-defined characteristics. Here, new compounds can be generated employing properties associated with zwitterions, dendrimers, or combination materials.
TECHNOLOGY...
Published: 6/19/2026
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Inventor(s): Chong Cheng, Mingxuan Zhang, Yun Wu, Ziwen Zhang
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics
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Netrin-4–Mediated Disruption of Basement Membranes for Targeted Therapeutic Delivery
Novel tools that promote the delivery of therapeutics to treat inner retinal diseases such as diabetic retinopathy, retinal vein occlusion, and retinitis pigmentosa.
Background:
Non-surgical access to tissues for direct biological manipulation, e.g. gene transfer, stem cell transplantation, and drug delivery, can be difficult because many tissues...
Published: 7/14/2026
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Inventor(s): Dale Hunter, William Brunken, Peter Yurchenco, Karen Mckee
Keywords(s): biologic therapies, drug delivery component, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines
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Lipid nanoparticles for targeted delivery of therapeutic agents in acute lung injury
This technology uses lung-targeting lipid nanoparticles to deliver a combination of anti-inflammatory and immune-modulating drugs directly to the lungs, offering a more effective and targeted treatment for acute lung injury and acute respiratory distress syndrome.
Background:
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...
Published: 4/2/2026
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Inventor(s): Yamin Li, Yuqin Men, Robert Cooney, Qinghe Meng
Keywords(s): acute lung injury, anti-inflammatory therapeutic, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
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Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells
This technology uses specially designed sulfonium lipid nanoparticles to deliver mRNA directly to lung cells through the nose, offering a non-invasive, more effective and targeted treatment for pulmonary diseases like asthma and cystic fibrosis.
Background:
The field of pulmonary medicine faces significant challenges in the treatment of diseases...
Published: 6/3/2026
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Inventor(s): Yamin Li, Yuqin Men
Keywords(s): active pharmaceutical ingredient, chemicals, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery
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