IgA Monoclonal Antibodies as a Prophylactic and Therapeutic Treatment for Dengue Virus Infection
Enables the prevention and treatment of dengue by avoiding the challenge of Antibody Dependent Enhancement. Background: Dengue virus is one of the most widespread vector-borne viral pathogens in the world. Nearly 400 million dengue virus infections occur each year, resulting in approximately 20,000 deaths. In addition, dengue-associated illness comprises...
Published: 8/20/2026
|
Inventor(s): Adam Waickman, Adam Wegman, Jeffrey Currier, Heather Friberg, Michael McCracken, Gregory Gromowski
Keywords(s): antibody, antibody therapy, biologics, biomedical, disease prevention, immunotherapy, monoclonal antibody, Technologies, viral immunology, viral pathogenesis
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies, Technology Classifications > Healthcare, Campus > Upstate Medical University
|
Multiplexed Saliva-based Immunodiagnostics for Assessing Anti-flavivirus Immunity
An easy-to-use method for rapidly, accurately, and non-invasively assessing flavivirus immunity by measuring various antibody classes present in saliva.
Background:
Flaviviruses (including dengue virus) are the most common vector-borne human viral pathogens in the world. Nearly 40% of the world’s population are at risk of infection with dengue...
Published: 8/19/2026
|
Inventor(s): Adam Waickman, Stephen Thomas, Frank Middleton
Keywords(s): antibodies, antibody, infectious diseases, saliva, Technologies, viral immunology
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
|
Combining Aminoglycoside Antibiotics and PKZ18 Analogs
Significantly enhances the efficacy of aminoglycosides drugs while reducing the risk of microbial drug resistance.
Background:
To increase drug efficacy and reduce the risk of the development of resistance to treatment, clinicians often prescribe multiple drugs of different classes in combination. For example, many topical creams use an aminoglycoside...
Published: 8/19/2026
|
Inventor(s): Ville Väre, Kathleen McDonough, Ryan Schneider, Paul Agris, Thorsten Seyler
Keywords(s): antibiotics, antimicrobial, drug development, Staphylococcus aureus, synergistic interaction, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
|
Ostomy leak detection system
The Ostomy Leak Detection System is an innovative technology designed to provide early and reliable detection of ostomy pouch leaks through an electrochemical sensor, enhancing patient comfort and health outcomes.
Background:
Ostomy pouch leakage is a common and challenging issue faced by individuals with ostomies. Leaks can cause extended skin exposure...
Published: 7/23/2026
|
Inventor(s): Fnu Alvina
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare
|
Topical Minocycline Ointment Suppresses Allergic Skin Responses
This technology presents a topical minocycline ointment formulated to effectively suppress allergic skin responses and reduce inflammation associated with allergic reactions.
Background:
Allergic skin reactions, such as hives, rashes, and inflammation caused by insect bites or contact with allergens, present common dermatological challenges that...
Published: 6/22/2026
|
Inventor(s): Rauno Joks, Helen Durkin (Deceased)
Keywords(s):
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Healthcare
|
Suppression of histamine and allergen induced itch and swelling with topical minocycline cream
This invention presents a topical 2% minocycline cream that significantly reduces histamine- and allergen-induced itching and swelling, offering a novel non-steroidal treatment for allergic skin reactions.
Background:
Allergic skin reactions, characterized by itching and swelling, affect many individuals and are commonly managed with steroid-based...
Published: 6/22/2026
|
Inventor(s): Rauno Joks
Keywords(s): Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Healthcare
|
Reduction of Lipid Accumulation Reverses Aging
Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis.
Background:
Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 8/31/2026
|
Inventor(s): Stylianos Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
|
Developing a new mechanism-based method to treat behavioral variant frontotemporal dementia
This technology offers a novel, mechanism-based therapeutic method using oxytocin and specific compounds to treat social-affective deficits in behavioral variant frontotemporal dementia (bvFTD).
Background:
Behavioral variant frontotemporal dementia (bvFTD) is a prevalent form of dementia characterized by severe social and emotional impairments,...
Published: 3/30/2026
|
Inventor(s): Wei-Dong Yao
Keywords(s): dementia, electrophysiology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
|
Lung-targeting mRNA-lipid nanoparticles for the treatment of acute lung injury
This technology uses lung-targeting lipid nanoparticles to deliver IL-10 mRNA directly to the lungs, reducing inflammation and injury in conditions like acute lung injury and ARDS, while minimizing side effects and improving treatment effectiveness.
Background:
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe, life-threatening...
Published: 8/4/2026
|
Inventor(s): Yamin Li, Yuqin Men, Qinghe Meng, Robert Cooney
Keywords(s): anti-inflammatory therapeutic, drug delivery, lipids, mRNA, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare
|
Self-delivery USP10 siRNA to promote regenerative healing-new IP
This technology employs an engineered self-delivering siRNA to selectively reduce USP10 protein levels in tissues, thereby promoting regenerative healing and suppressing pathological scarring. Preclinical studies in the eye demonstrate a favorable safety profile and robust efficacy, supporting the potential of this approach for treating fibrotic disease...
Published: 3/18/2026
|
Inventor(s): Audrey Bernstein, Sean McCauley, Alexey Wolfson, Tere Williams
Keywords(s): fibrosis, opthalmology, scarring, siRNA, skin diseases, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Campus > Upstate Medical University
|