Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 11/20/2024
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Determining Bloodstain Age Using Raman Spectroscopy
A novel and non-destructive method of determining the age of an evidentiary bloodstain using Raman Spectroscopy. Background: Forensic investigators are members of law enforcement that help secure a crime scene and collect evidence. When the evidence involves blood, the age of that blood is a critical piece of information investigators need to identify...
Published: 11/1/2024
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Inventor(s): Igor Lednev
Keywords(s): TAF, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering
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RNA-aptamer-mediated Bacteriophage Purification
A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes.
Background:
Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...
Published: 10/3/2024
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Inventor(s): Ing-Nang Wang, Hua Shi, Jia Sheng, Alan Chen
Keywords(s): bacteriophage purification, phage purification, phage therapy, RNA aptamer, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
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Raman Spectroscopy for Testing Stability of RNA-based Vaccines and Drugs
A fast, less expensive, and more reliable method for assessing mRNA degradation in vaccines, that can also be used as a tool for the development of new RNA-based therapeutics.
Background:
The development of mRNA-based vaccines for COVID-19 offers the potential for a new medical paradigm based on RNA technology. Unfortunately, these drugs require...
Published: 10/3/2024
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Inventor(s): Igor Lednev, Alexander Shekhtman, Lamyaa Almehmadi, Sergei Reverdatto
Keywords(s): drug stability, mRNA, mRNA stability, Raman spectroscopy, RNA, Technologies, vaccine stability, vaccines
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Viral Vectors
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Suppression of Therapeutic Escape in Breast Cancer by BTK Inhibition
This technology offers the potential of new and novel cancer treatments based on various inhibitors of protein tyrosine kinases
Background:
Genes that regulate extracellular growth, differentiation, and developmental signals are commonly mutated in cancers. Protein tyrosine kinases (PTKs) mediate the reversible process of tyrosine phosphorylation,...
Published: 9/5/2024
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Inventor(s): Douglas Conklin, Xianhui Wang
Keywords(s): breast cancer, cancer, Technologies, therapeutic targets
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Therapeutics and Vaccines
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In Vitro Dental Plaque Culture Model for Biofilm Structural Analyses
This technology provides a valuable tool for studying the molecular and cellular basis of dental plaque-mediated diseases.
Background:
In vitro oral microcosm communities, seeded with mixed communities of human dental plaque, have proven to be essential tools for studying the taxonomic composition of dental plaque communities and changes in community...
Published: 10/3/2024
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Inventor(s): Alex Valm
Keywords(s): biofilm control, dental, dental materials, structural biology, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Dental, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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NRN-EZ: An application to streamline biophysical modeling of synaptic integration using NEURON
NRN-EZ is an interactive application that allows NEURON users without extensive programming experience to define complex patterns of synaptic input activation.
Background:
Modeling software programs such as NEURON are widely used in the neuroscience community to address a broad range of research questions, including how neurons integrate synaptic...
Published: 9/26/2024
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Inventor(s): Annalisa Scimemi, Evan Cobb
Keywords(s): neuron, software, synapic integration, synapse, Technologies
Category(s): Technology Classifications > Information Technology, Campus > University at Albany, Technology Classifications > Education and Training, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering
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High-Frequency, Device-Free mmWave Facial Landmark Sensing
A high-resolution, non-contact facial landmark tracking system that uses millimeter wave (mmWave) technology to achieve precise and efficient facial sensing.
Background:
MicroFace introduces a novel mmWave-based system for high-resolution, non-contact facial landmark tracking. This system addresses the existing challenge of precise and efficient...
Published: 9/10/2024
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Inventor(s): Wenyao Xu, Chenhan Xu
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Sensors, Technology Classifications > Information Technology
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Biocogent
https://www.biocogent.com/
https://www.biocogent.com/
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Published: 6/7/2024
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Inventor(s):
Keywords(s): Startups
Category(s): Campus > Stony Brook University, Technology Classifications > Biomedical Science and Engineering
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Cross Finger Biometric Verification
Improved digital authentication systems that allow users to enroll with one finger and unlock with any other finger.
Background:
Fingerprints have long been regarded as one of the most reliable forms of biometric identification due to their presumed uniqueness. The distinct patterns and ridges on each individual's fingertips have served as a...
Published: 5/10/2024
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Inventor(s): Wenyao Xu, Hod Lipson, Aniv Ray, Gabriel Guo
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Information Technology
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