A 3D printable mini-gel electrophoresis system and methods for use
This technology is a low-cost, 3D printable mini-gel electrophoresis system with built-in electrodes, enabling rapid, portable DNA analysis using battery power—ideal for education, fieldwork, and labs with limited resources.
Background:
Gel electrophoresis is a cornerstone technique in molecular biology, widely used for the separation and analysis...
Published: 3/9/2026
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Inventor(s): Kenneth Halvorsen, Andrew Hayden, Vinod Morya
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics
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Improving the sensitivity and range of detection with ligation of DNA nanoswitches
This technology uses enzymatic ligation in DNA nanoswitches to detect very short or rare DNA and RNA sequences with high sensitivity, amplifying signals by recycling targets so even single molecules can be identified for diagnostics and research.
Background:
Nucleic acid detection is a cornerstone of modern molecular biology, diagnostics, and biotechnology,...
Published: 3/9/2026
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Inventor(s): Kenneth Halvorsen, Jibin Punnoose, Vinod Morya
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering
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Expanding DNA nanoswitch utility with detection by aptamers
This technology integrates aptamers into DNA nanoswitches, enabling sensitive detection of a wide range of biomolecules—including proteins and small molecules—for use in diagnostics, research, and biosensing applications.
Background:
Molecular detection technologies are foundational in fields such as diagnostics, biomedical research,...
Published: 3/9/2026
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Inventor(s): Kenneth Halvorsen, Arun Richard Chandrasekaran
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering
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Methods for detecting RNA modifications with DNA nanoswitches
This technology uses DNA nanoswitches to directly and specifically detect RNA modifications, allowing simultaneous identification of multiple modifications in their natural sequence context for research, diagnostics, and drug discovery applications.
Background:
RNA modifications, such as methylation, play critical roles in gene regulation, cellular...
Published: 3/9/2026
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Inventor(s): Kenneth Halvorsen, Iranna Todkari, Andrew Hayden
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Design and Synthesis
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Targeting RNA Polymerase I Protein–Protein Interfaces Using Peptide Inhibitors:
A Computational Strategy Powered by PepTelligence, a Comprehensive Peptide Scoring System
PepTelligence is an innovative computational tool designed to evaluate and optimize therapeutic peptides by integrating multiple biochemical and pharmacological factors into a unified scoring system.
Background:
The development of PepTelligence addresses a significant challenge in peptide drug discovery: the absence of a comprehensive evaluation...
Published: 2/25/2026
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Inventor(s): Maryam Kabiri, Bruce Knutson
Keywords(s): multi-parameter scoring, peptide design, peptide drug discovery, peptide scoring system, structural bioinformatics, Technologies, therapeutic peptides
Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
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A novel synthetic constitutive-active glucocorticoid receptor
Introducing "superGR," a novel synthetic glucocorticoid receptor fusion protein designed to enhance glucocorticoid therapy by providing ligand-independent activation and improved gene regulation for inflammatory diseases.
Background:
Glucocorticoids are widely used to treat inflammatory conditions like severe alcoholic hepatitis and sepsis, but their...
Published: 3/9/2026
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Inventor(s): Hong Lu, Conor Fahy
Keywords(s): gene therapy, glucocorticoid, inflammatory liver disease, lung injury, sepsis, synthetic materials, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
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Luminescent biosensor for detection of nucleotide sequences, small molecules, and proteins at the point-of-care
This technology is a modular, luminescent biosensor that rapidly detects DNA, RNA, small molecules, and proteins at the point of care, using a visible color change measurable by a smartphone, enabling fast, sensitive, and equipment-free diagnostics.
Background:
Molecular diagnostics is a rapidly evolving field that plays a critical role in the detection...
Published: 3/9/2026
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Inventor(s): Harsimranjit Sekhon, Stewart Loh
Keywords(s): bio/chemical sensors, bioluminescence, biomarker diagnostics, biosensor, nanoluciferase, Technologies, therapeutic drug monitoring, Virus Detection
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics
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Dual Inhibition of RNA Polymerase I and III as a Novel Strategy for Targeting Ribosome Biogenesis in Cancer
A specially designed peptide blocks two key enzymes needed for ribosome production in cancer cells, shutting down their protein-making machinery and offering a new, more effective way to treat cancer and prevent drug resistance.
Background:
Ribosome biogenesis is a fundamental cellular process involving the coordinated synthesis of ribosomal RNA...
Published: 3/9/2026
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Inventor(s): Haleigh Pascual, Bruce Knutson
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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Targeted Immune-Activating Antibody Conjugates for Cancer and Infectious Disease Therapy
This technology enables precise activation of the immune system by delivering potent TLR7/8 agonists directly to diseased cells. By combining immune stimulators with antibody targeting, it enhances therapeutic impact while minimizing systemic side effects. The approach offers a safer and more effective way to treat cancer and infectious diseases by...
Published: 2/13/2026
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Inventor(s): Lawrence Tumey, Emmanuel Olawode
Keywords(s): Technologies, XCEED
Category(s): Campus > Binghamton University, Technology Classifications > Biomedical Science and Engineering
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Novel three-dimensional, conformal microelectrode arrays for interrogating and manipulating three-dimensional cell culture systems
A flexible, biocompatible microelectrode array wraps around 3D cell cultures such as organoids, enabling comprehensive electrical recording and stimulation for advanced research, drug testing, and personalized medicine, overcoming the limitations of traditional flat electrode arrays.
Background:
Three-dimensional (3D) cell culture systems, such as...
Published: 2/18/2026
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Inventor(s): Susan Sharfstein, Nathaniel Cady, Yubing Xie, Natalya Tokranova, Anthony Manning, Fernando Pesantez Torres
Keywords(s): 3D culture, 3D flexible microelectrode, electrophysiology, microelectrode array, microfabrication, neurodegeneration, organoid, polymer materials, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering
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