β-Catenin agonists recapitulate the protective effects of genetic stabilization
This technology uses drugs that stabilize β-catenin to boost protective immune cells in the lungs, reducing damage from pulmonary hemorrhage and inflammatory lung diseases by activating a novel immunomodulatory pathway.
Background:
Pulmonary hemorrhage and other inflammatory lung diseases represent significant clinical challenges due to their...
Published: 3/24/2026
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Inventor(s): Mobin Karimi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
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Harnessing IL15C and NKG2D for Potent and Persistent CAR T Cell Therapy in TNBC
This technology is an advanced CAR T-cell therapy for triple-negative breast cancer that uses engineered T-cells to recognize and kill cancer cells regardless of HLA status and includes a built-in IL-15 signal to boost T-cell survival and effectiveness.
Background:
Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype of breast...
Published: 3/24/2026
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Inventor(s): Mobin Karimi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
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Functionalized Dendrimers with Regioselective Reactivity
Novel compositions of zwitterionic dendrimers and derived polymers
BACKGROUND:
There is a strong need for new classes of reactive reagents for the generation of novel materials with pre-defined characteristics. Here, new compounds can be generated employing properties associated with zwitterions, dendrimers, or combination materials.
TECHNOLOGY...
Published: 3/24/2026
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Inventor(s): Chong Cheng, Mingxuan Zhang, Yun Wu, Ziwen Zhang
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics
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Liquid Biopsy Detection of TF-Ag-α-Positive Cancer-Associated Exosomes
A liquid biopsy assay detecting TF-Ag-α–positive tumor-derived exosomes for cancer screening, early detection and treatment monitoring.
Background:
Cancer diagnostics are rapidly evolving as early detection and treatment monitoring are critical to improving patient outcomes. Traditional methods such as imaging and tissue biopsies are...
Published: 3/23/2026
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Inventor(s): Grace Dy, Yun Wu, Kate Rittenhouse-Olson
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Engineering, Technology Classifications > Medical Devices, Technology Classifications > Sensors
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Self-delivery USP10 siRNA to promote regenerative healing-new IP
This technology employs an engineered self-delivering siRNA to selectively reduce USP10 protein levels in tissues, thereby promoting regenerative healing and suppressing pathological scarring. Preclinical studies in the eye demonstrate a favorable safety profile and robust efficacy, supporting the potential of this approach for treating fibrotic disease...
Published: 3/18/2026
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Inventor(s): Audrey Bernstein, Sean McCauley, Alexey Wolfson, Tere Williams
Keywords(s): fibrosis, opthalmology, scarring, siRNA, skin diseases, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Campus > Upstate Medical University
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Improving the sensitivity and range of detection with ligation of DNA nanoswitches
This technology uses enzymatic ligation in DNA nanoswitches to detect very short or rare DNA and RNA sequences with high sensitivity, amplifying signals by recycling targets so even single molecules can be identified for diagnostics and research.
Background:
Nucleic acid detection is a cornerstone of modern molecular biology, diagnostics, and biotechnology,...
Published: 3/11/2026
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Inventor(s): Kenneth Halvorsen, Jibin Punnoose, Vinod Morya
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering
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A 3D printable mini-gel electrophoresis system and methods for use
This technology is a low-cost, 3D printable mini-gel electrophoresis system with built-in electrodes, enabling rapid, portable DNA analysis using battery power—ideal for education, fieldwork, and labs with limited resources.
Background:
Gel electrophoresis is a cornerstone technique in molecular biology, widely used for the separation and analysis...
Published: 3/9/2026
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Inventor(s): Kenneth Halvorsen, Andrew Hayden, Vinod Morya
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics
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Expanding DNA nanoswitch utility with detection by aptamers
This technology integrates aptamers into DNA nanoswitches, enabling sensitive detection of a wide range of biomolecules—including proteins and small molecules—for use in diagnostics, research, and biosensing applications.
Background:
Molecular detection technologies are foundational in fields such as diagnostics, biomedical research,...
Published: 3/9/2026
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Inventor(s): Kenneth Halvorsen, Arun Richard Chandrasekaran
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering
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Methods for detecting RNA modifications with DNA nanoswitches
This technology uses DNA nanoswitches to directly and specifically detect RNA modifications, allowing simultaneous identification of multiple modifications in their natural sequence context for research, diagnostics, and drug discovery applications.
Background:
RNA modifications, such as methylation, play critical roles in gene regulation, cellular...
Published: 3/9/2026
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Inventor(s): Kenneth Halvorsen, Iranna Todkari, Andrew Hayden
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Design and Synthesis
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Targeting RNA Polymerase I Protein–Protein Interfaces Using Peptide Inhibitors:
A Computational Strategy Powered by PepTelligence, a Comprehensive Peptide Scoring System
PepTelligence is an innovative computational tool designed to evaluate and optimize therapeutic peptides by integrating multiple biochemical and pharmacological factors into a unified scoring system.
Background:
The development of PepTelligence addresses a significant challenge in peptide drug discovery: the absence of a comprehensive evaluation...
Published: 2/25/2026
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Inventor(s): Maryam Kabiri, Bruce Knutson
Keywords(s): multi-parameter scoring, peptide design, peptide drug discovery, peptide scoring system, structural bioinformatics, Technologies, therapeutic peptides
Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
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