Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy
050-9150 Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy
A unique immunotherapy paradigm to treat castrate-resistant prostate cancer and its metastatic form
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Prostate cancer is one of the leading causes of cancer death, with 1 in 10 men diagnosed in their lifetime and 1 in 41 dying from the...
Published: 9/25/2024
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Inventor(s): Labros Meimetis, Eszter Boros
Keywords(s): Technologies
Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics, Campus > Stony Brook University
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Enzymatic Capsulotomy for Shoulder Adhesive Capsulitis
A minimally invasive collagenase injection method for treating frozen shoulder that is cost-effective Background: Adhesive capsulitis of the shoulder, more commonly known as frozen shoulder, results in painful limitation of shoulder motion. It can arise idiopathically or after trauma. The current standard of care is a long course of painful physical...
Published: 11/22/2023
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Inventor(s): Marie Badalamente, Edward Wang
Keywords(s): Collagenase Injection, Frozen shoulder, Nonoperative Therapy, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Therapeutics
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Alkene Isomerization as an Entry to Efficient Alternating Ring-opening Metathesis Polymerization (iAROMP)
A technique that enables the preparation of long length and low dispersion polymers with an alternating functional group arrangement Background: Most sequence-controlled polymers lack rigorous fidelity or are homopolymers with simple chain microstructures or copolymers, in which the monomer sequence is not precisely controlled. Polymers of imprecise...
Published: 8/28/2024
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Inventor(s): Nicole Sampson, Li Tan, Kathlyn Parker
Keywords(s): alkene isomerization, Grubbs catalyst, ROMP, ruthenium, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Research Tools and Reagents
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Novel Bioabsorbable Membranes for Cell Delivery Applications
Methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system. Background: Methods and compositions for encapsulating core materials, e.g., materials containing drugs, have been disclosed. These methods generally involve encapsulating the core material within a micro capsule by forming...
Published: 11/22/2023
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Inventor(s): Benjamin Chu, Benjamin Hsiao, Michael Hadjiargyrou, Dufei Fang, Xinhua Zong, KwangSok Kim
Keywords(s):
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Gene Therapy and Viral Vectors
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Novel Drugs for the Treatment of Tuberculosis
Compounds that increase TB therapy efficacy through a mechanism of action for increased tolerance and decreased therapy duration. Background: One third of the world's population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. The current recommended treatment regimen for TB begins with a two-month intensive therapy...
Published: 8/27/2024
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Inventor(s): Nicole Sampson, Xinxin Yang, Tianao Yuan
Keywords(s):
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis
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Novel Inhibitors of Matrix Metalloproteinase-9 for Anti-Cancer Drug Development
Inhibitors that target a site on MMP-9's hemopexin domain that are distinct and cannot be functionally substituted for one another. Background: Matrix Metalloproteinase-9 (MMP-9), a type IV collagenase, is linked to cancer progression and metastasis. Despite increased evidence of correlation between MMP-9 and tumor metastasis, no success has been...
Published: 9/27/2024
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Inventor(s): Vincent Alford, Anushree Kamath, Jian Cao, Nicole Sampson, Iwao Ojima, Xiaodong Ren, Monaf Awwa
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Research Tools and Reagents
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Antiviral Compounds with a Unique Mechanism of Action
Host-directed viral inhibitors that target a highly conserved cellular machinery necessary for the viral life cycle. Background: HIV is a major global public health problem that lacks a cure, however available anti retrovirals have been successful in improving and extending the quality of life in patients. This success has recently encountered a set-back...
Published: 2/28/2024
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Inventor(s): Carol Carter, Lorna Ehrlich
Keywords(s): Technologies
Category(s): Campus, Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Therapeutics
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BRIKARD: Builder of Recursive Inverse Kinematic Assembly and Ring Design
Predicting conformations of artificial macrocycles and their interaction with target proteins. Background: Macrocycles (MCs) are an extremely promising class of new drugs with a broad range of therapeutic applications. The challenge is they are hard to design using conventional “wet” combinatorial methods which makes in silico approaches...
Published: 8/27/2024
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Inventor(s): Evangelos Coutsias, Michael Wester
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis
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Triazine-Based Tripod Linker System for Drug Delivery and Diagnosis
This tumor-targeted drug delivery system uses biotin as a tumor targeting moiety and taxoid-camptothecin combination. Background: Combination therapy is the primary treatment option against cancer, because multiple agents in combination, synergistically improve efficacy and are less prone to resistance due to their distinct action mechanisms. Despite...
Published: 8/27/2024
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Inventor(s): Iwao Ojima, Jacob Vineberg, Tao Wang
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Technology Classifications > Diagnostics, Technology Classifications > Therapeutics
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Novel 18F-Labeled PET-Tracers for Use in Treatment of Neurological Disorders
Novel 18F-labeled GSK3β inhibitors that can cross the blood brain barrier. Background: Dysregulation of Glycogen Synthase Kinase 3β (GSK3β) is associated with several neurodegenerative diseases, such as Parkinson’s, Alzheimer’s and Huntington’s. Therefore, development of a selective GSK3β PET tracer would enable...
Published: 3/20/2024
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Inventor(s): Ming-Yu Ngai, Katarzyna Lee, Kongzhen Hu *credit to use, Neil Nasdev, Stephen Haggarty
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Diagnostics, Technology Classifications > Therapeutics
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