Developing a new mechanism-based method to treat behavioral variant frontotemporal dementia
This technology offers a novel, mechanism-based therapeutic method using oxytocin and specific compounds to treat social-affective deficits in behavioral variant frontotemporal dementia (bvFTD).
Background:
Behavioral variant frontotemporal dementia (bvFTD) is a prevalent form of dementia characterized by severe social and emotional impairments,...
Published: 3/30/2026
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Inventor(s): Wei-Dong Yao
Keywords(s): dementia, electrophysiology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Computer vision-based human movement analysis for physical therapists and trainers
This technology is a computer vision-based software platform that enables real-time human movement analysis, providing physical therapists and trainers with objective feedback and progress tracking through a standard webcam.
Background:
Traditional physical therapy and fitness training often rely on subjective visual assessments, which can limit...
Published: 3/30/2026
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Inventor(s): Bokkyu Kim
Keywords(s): medical devices, medical imaging, Technologies
Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University
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β-Catenin agonists recapitulate the protective effects of genetic stabilization
This technology uses drugs that stabilize β-catenin to boost protective immune cells in the lungs, reducing damage from pulmonary hemorrhage and inflammatory lung diseases by activating a novel immunomodulatory pathway.
Background:
Pulmonary hemorrhage and other inflammatory lung diseases represent significant clinical challenges due to their...
Published: 3/30/2026
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Inventor(s): Mobin Karimi
Keywords(s): gene coding, gene therapies, gene therapy, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
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Harnessing IL15C and NKG2D for Potent and Persistent CAR T Cell Therapy in TNBC
This technology is an advanced CAR T-cell therapy for triple-negative breast cancer that uses engineered T-cells to recognize and kill cancer cells regardless of HLA status and includes a built-in IL-15 signal to boost T-cell survival and effectiveness.
Background:
Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype of breast...
Published: 3/30/2026
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Inventor(s): Mobin Karimi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
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Lung-targeting mRNA-lipid nanoparticles for the treatment of acute lung injury
This technology uses lung-targeting lipid nanoparticles to deliver IL-10 mRNA directly to the lungs, reducing inflammation and injury in conditions like acute lung injury and ARDS, while minimizing side effects and improving treatment effectiveness.
Background:
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe, life-threatening...
Published: 3/19/2026
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Inventor(s): Yamin Li, Yuqin Men, Qinghe Meng, Robert Cooney
Keywords(s): anti-inflammatory therapeutic, drug delivery, lipids, mRNA, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare
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Self-delivery USP10 siRNA to promote regenerative healing-new IP
This technology employs an engineered self-delivering siRNA to selectively reduce USP10 protein levels in tissues, thereby promoting regenerative healing and suppressing pathological scarring. Preclinical studies in the eye demonstrate a favorable safety profile and robust efficacy, supporting the potential of this approach for treating fibrotic disease...
Published: 3/18/2026
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Inventor(s): Audrey Bernstein, Sean McCauley, Alexey Wolfson, Tere Williams
Keywords(s): fibrosis, opthalmology, scarring, siRNA, skin diseases, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Campus > Upstate Medical University
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Diabetic Foot Examiner
This technology enables diabetic patients to detect foot ulcers easily and effectively at home.
Background:
Diabetic foot ulcers are a significant health problem (15% baseline probability) in the growing diabetic population. Foot ulcers can become infected and lead to hospitalization or even amputation. The best way to address this disease is through...
Published: 3/13/2026
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Inventor(s): Ronald Miller
Keywords(s): artificial intelligence, diabetes, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare
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3D-Printed Theranostic Dose Caddy
This technology enables safer administration of radioligand therapies, allowing for healthier, lower radiation doses to both patients and administering staff.
Background:
At present, there are two FDA-approved radioligand therapies for broad use in cancer treatment: Lutathera (177Lutetium DOTATATE) and Pluvicto (177Lutetium Vipivotide Tetraxetan)....
Published: 3/13/2026
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Inventor(s): David Lubin, David Feiglin, Kurtis Wilson, Leen Alkukhun, Garrett Depalma, Kent Ogden, Mary McGrath, Paul Depew, Zohaib Khan, Meghan Stanton
Keywords(s): 3D printing, cancer therapy, radiology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare
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Netrin-4–Mediated Disruption of Basement Membranes for Targeted Therapeutic Delivery
Novel tools that promote the delivery of therapeutics to treat inner retinal diseases such as diabetic retinopathy, retinal vein occlusion, and retinitis pigmentosa.
Background:
Non-surgical access to tissues for direct biological manipulation, e.g. gene transfer, stem cell transplantation, and drug delivery, can be difficult because many tissues...
Published: 3/9/2026
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Inventor(s): Dale Hunter, William Brunken, Peter Yurchenco, Karen Mckee
Keywords(s): biologic therapies, drug delivery component, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines
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Modular Hybrid Simulator (Endovascular Flow model with embedded sensors for operative feedback) powered by 3D auto segmentation software for Endovascular Modeling and Flow Model additions.
The Modular Hybrid Simulator is an advanced training platform for endovascular procedures, combining patient-specific 3D modeling with real-time operative feedback to enhance learning and procedural planning.
Background:
Endovascular training currently faces challenges such as inconsistent learning curves among trainees and the limitations of existing...
Published: 3/3/2026
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Inventor(s): Hesham Masoud
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare
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