Use of Probenecid as an Anti-Virulence Agent Against Listeria monocytogenes
This technology repurposes the FDA-approved drug small molecule as an anti-virulence agent to combat Listeria monocytogenes by reducing its pathogenicity while having minimal effects on bacterial growth under the tested in-vitro conditions..
Background:
Listeria monocytogenes is a harmful bacterium responsible for listeriosis, a serious infection...
Published: 9/2/2026
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Inventor(s): Aaron Glass, Steven Taffet
Keywords(s): antibacterial, antibiotics, bacterial infection, bacterial pathogenesis, drug repurposing, drug targeting, small molecule therapeutics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
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COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING SCARRING AND INFLAMMATION IN THE EYE
This invention presents novel compositions and methods employing self-delivering siRNA (sdRNA) targeting USP10 to prevent and treat scarring and inflammation in the eye following glaucoma filtration and other intraocular pressure-lowering surgeries.
Background:
Glaucoma filtration surgery and other procedures designed to reduce intraocular pressure...
Published: 8/27/2026
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Inventor(s): Audrey Bernstein
Keywords(s): animal models, fibrosis, glaucoma, inflammation, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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A HNF4a-caGR fusion transcription factor as potential treatment for inflammatory liver diseases and liver cancer
The HNF4α-caGR fusion transcription factor is an innovative therapeutic protein designed to restore liver function and reduce inflammation in liver diseases and liver cancer by simultaneously activating key regulatory pathways.
Background:
Liver diseases and liver cancer often involve impaired function of hepatocyte nuclear factor 4α...
Published: 8/27/2026
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Inventor(s): Hong Lu
Keywords(s): anticancer therapeutic, anti-inflammatory therapeutic, gene therapy, liver disease, sepsis, Technologies, tumor suppressor genes
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
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IgA Monoclonal Antibodies as a Prophylactic and Therapeutic Treatment for Dengue Virus Infection
Enables the prevention and treatment of dengue by avoiding the challenge of Antibody Dependent Enhancement. Background: Dengue virus is one of the most widespread vector-borne viral pathogens in the world. Nearly 400 million dengue virus infections occur each year, resulting in approximately 20,000 deaths. In addition, dengue-associated illness comprises...
Published: 8/20/2026
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Inventor(s): Adam Waickman, Adam Wegman, Jeffrey Currier, Heather Friberg, Michael McCracken, Gregory Gromowski
Keywords(s): antibody, antibody therapy, biologics, biomedical, disease prevention, immunotherapy, monoclonal antibody, Technologies, viral immunology, viral pathogenesis
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies, Technology Classifications > Healthcare, Campus > Upstate Medical University
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Multiplexed Saliva-based Immunodiagnostics for Assessing Anti-flavivirus Immunity
An easy-to-use method for rapidly, accurately, and non-invasively assessing flavivirus immunity by measuring various antibody classes present in saliva.
Background:
Flaviviruses (including dengue virus) are the most common vector-borne human viral pathogens in the world. Nearly 40% of the world’s population are at risk of infection with dengue...
Published: 8/19/2026
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Inventor(s): Adam Waickman, Stephen Thomas, Frank Middleton
Keywords(s): antibodies, antibody, infectious diseases, saliva, Technologies, viral immunology
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Procedure for Pre-Clinical Continuous EEG/ECG Monitoring
This technology introduces a novel surgical procedure, custom implant, and wiring harness for continuous electroencephalogram (EEG) and electrocardiogram (ECG) monitoring in conscious unrestrained animals. The animal is chronically implanted with subdermal electrodes and connected to a durable wiring system to capture high-quality physiological data....
Published: 8/6/2026
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Inventor(s): David Auerbach, Kyle Wagner, Laura Williams
Keywords(s): animal models, animal studies, bioengineering, biomedical science, biosensor, electrocardiogram, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Diagnostics
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Luminescent biosensor for detection of nucleotide sequences, small molecules, and proteins at the point-of-care
This technology is a modular, luminescent biosensor that rapidly detects DNA, RNA, small molecules, and proteins at the point of care, using a visible color change measurable by a smartphone, enabling fast, sensitive, and equipment-free diagnostics.
Background:
Molecular diagnostics is a rapidly evolving field that plays a critical role in the detection...
Published: 8/4/2026
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Inventor(s): Harsimranjit Sekhon, Stewart Loh
Keywords(s): bio/chemical sensors, bioluminescence, biomarker diagnostics, biosensor, nanoluciferase, Technologies, therapeutic drug monitoring, Virus Detection
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics
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Ostomy leak detection system
The Ostomy Leak Detection System is an innovative technology designed to provide early and reliable detection of ostomy pouch leaks through an electrochemical sensor, enhancing patient comfort and health outcomes.
Background:
Ostomy pouch leakage is a common and challenging issue faced by individuals with ostomies. Leaks can cause extended skin exposure...
Published: 7/23/2026
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Inventor(s): Fnu Alvina
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare
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Single Use Minimally Invasive Orthopedic Bone Biopsy and Graft Introduction Tray
The Single Use Minimally Invasive Orthopedic Bone Biopsy and Graft Introduction Tool Tray is an all-inclusive, innovative tool tray designed to improve the efficiency and effectiveness of orthopedic macro biopsies through a safe, secure, controlled minimally invasive approach even through normal intact cortical bone.
Background:
Orthopedic surgeons...
Published: 6/29/2026
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Inventor(s): Timothy Damron
Keywords(s): biopsy, bone, bone filler, bone graft, minimally invasive, orthopedic oncology, orthopedic surgery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
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Customizable implantable testicular prosthetics
This innovation introduces a customizable implantable testicular prosthesis with an adjustable size, enabling precise fit and improved surgical outcomes.
Background:
Existing testicular prosthetics are typically available as either pre-sized balloon-type implants or solid silicone models. These fixed-size options often present challenges during surgery,...
Published: 6/29/2026
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Inventor(s): Dmitriy Nikolavsky, Gennady Bratslavsky
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Assistive Technology
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