Targeting RNA Polymerase I Protein–Protein Interfaces Using Peptide Inhibitors:
A Computational Strategy Powered by PepTelligence, a Comprehensive Peptide Scoring System
PepTelligence is an innovative computational tool designed to evaluate and optimize therapeutic peptides by integrating multiple biochemical and pharmacological factors into a unified scoring system.
Background:
The development of PepTelligence addresses a significant challenge in peptide drug discovery: the absence of a comprehensive evaluation...
Published: 2/25/2026
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Inventor(s): Maryam Kabiri, Bruce Knutson
Keywords(s): multi-parameter scoring, peptide design, peptide drug discovery, peptide scoring system, structural bioinformatics, Technologies, therapeutic peptides
Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
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A novel synthetic constitutive-active glucocorticoid receptor
Introducing "superGR," a novel synthetic glucocorticoid receptor fusion protein designed to enhance glucocorticoid therapy by providing ligand-independent activation and improved gene regulation for inflammatory diseases.
Background:
Glucocorticoids are widely used to treat inflammatory conditions like severe alcoholic hepatitis and sepsis, but their...
Published: 2/19/2026
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Inventor(s): Hong Lu, Conor Fahy
Keywords(s): gene therapy, glucocorticoid, inflammatory liver disease, lung injury, sepsis, synthetic materials, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
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Luminescent biosensor for detection of nucleotide sequences, small molecules, and proteins at the point-of-care
This technology is a modular, luminescent biosensor that rapidly detects DNA, RNA, small molecules, and proteins at the point of care, using a visible color change measurable by a smartphone, enabling fast, sensitive, and equipment-free diagnostics.
Background:
Molecular diagnostics is a rapidly evolving field that plays a critical role in the detection...
Published: 2/19/2026
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Inventor(s): Harsimranjit Sekhon, Stewart Loh
Keywords(s): bio/chemical sensors, bioluminescence, biomarker diagnostics, biosensor, nanoluciferase, Technologies, therapeutic drug monitoring, Virus Detection
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics
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Dual Inhibition of RNA Polymerase I and III as a Novel Strategy for Targeting Ribosome Biogenesis in Cancer
A specially designed peptide blocks two key enzymes needed for ribosome production in cancer cells, shutting down their protein-making machinery and offering a new, more effective way to treat cancer and prevent drug resistance.
Background:
Ribosome biogenesis is a fundamental cellular process involving the coordinated synthesis of ribosomal RNA...
Published: 2/19/2026
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Inventor(s): Haleigh Pascual, Bruce Knutson
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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Generation of a single-chain recombinant IgA1 isotype antibody compatible with in vivo nucleic acid delivery for the treatment and prevention of flavivirus infection
This technology uses a single-chain IgA1 antibody delivered by DNA or RNA to enable the body to produce its own protection against dengue and Zika viruses, offering rapid, safe, and scalable prevention and treatment without risk of antibody-dependent enhancement.
Background:
Flavivirus infections, including those caused by dengue and Zika viruses,...
Published: 2/17/2026
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Inventor(s): Adam Waickman, Stephen Thomas
Keywords(s): antibody therapy, infectious diseases, nucleic acid, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare
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Use of recombinant IgA1 isotype mAbs to prevent and antagonize transplacental transmission of flaviviruses in pregnant women
This technology is a single-chain IgA1 antibody delivered by DNA or RNA, enabling the body to produce its own dengue-neutralizing antibodies safely and quickly, without the risk of worsening infection, for rapid prevention and treatment of flavivirus diseases.
Background:
The field of flavivirus therapeutics, particularly for diseases like dengue,...
Published: 2/17/2026
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Inventor(s): Adam Waickman, Stephen Thomas
Keywords(s): infectious diseases, monoclonal antibodies, pregnancy, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare
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DEVICE FOR ORAL FLUID COLLECTION CONSISTING OF ABSORBANT MATERIAL AND NESTED TUBES REQUIRING CENTRIFUGATION
This is a simple, low-cost device using absorbent material and nested tubes to collect clean, mucous-free oral fluid samples by centrifugation, making sample collection easier, more hygienic, and affordable for labs and research.
Background:
Oral fluid collection is an essential process in various fields, including clinical diagnostics, biomedical...
Published: 2/13/2026
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Inventor(s): Aaron Glass
Keywords(s): saliva, Salivary biomarkers, specimen collection, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics
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HistoTME: an AI tool for prediction of the tumor microenvironment molecular composition from histopathology images
HistoTME is an AI software that predicts the tumor microenvironment’s molecular makeup from standard pathology images, helping identify lung cancer patients likely to benefit from immunotherapy without needing costly molecular tests.
Background:
The tumor microenvironment (TME) plays a crucial role in the progression and treatment response...
Published: 2/3/2026
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Inventor(s): Tamara Jamaspishvili, Sushant Patkar, Alex Chen, Stephanie Harmon, Ismail Turkbey
Keywords(s): artificial intelligence, cancer, computational biology, digital image processing, disease diagnosis, Technologies
Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University, Technology Classifications > Medical Imaging
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Pharmacological strategy to treat hydrocephalus
This technology offers a non-surgical treatment for hydrocephalus by using drugs to enhance the removal of harmful macromolecules from the brain’s ventricles, targeting specific cellular transport mechanisms to reduce fluid buildup and disease progression.
Background:
Hydrocephalus is a neurological disorder characterized by the abnormal accumulation...
Published: 1/29/2026
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Inventor(s): Satish Krishnamurthy, David Lehmann
Keywords(s): hydrocephalus, pharmacology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare
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“Smart” Electronic Rotating Hemostatic Valve and Tuohy-Borst Adapter with Integrated Activation and Force Sensors with Interface with Heads-Up Electronic Displays and Cloud-Based Data Analysis To Optimize Technical Safety, Display Live Quantified Operator Variables and Inform Individualized Procedural Technique
This technology measures, records, and displays force measurements exerted on catheters, providing valuable data to improve patient outcomes.
Background:
Rotating hemostatic valves (RHV) and Tuohy-Borst adapters (TBA) are used with catheter-based and other relevant procedures. Currently available RHVs and TBAs lack integrated sensors to provide feedback...
Published: 1/29/2026
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Inventor(s): Hesham Masoud, Andrew Decker
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare
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