Generation of a single-chain recombinant IgA1 isotype antibody compatible with in vivo nucleic acid delivery for the treatment and prevention of flavivirus infection
This technology uses a single-chain IgA1 antibody delivered by DNA or RNA to enable the body to produce its own protection against dengue and Zika viruses, offering rapid, safe, and scalable prevention and treatment without risk of antibody-dependent enhancement.
Background:
Flavivirus infections, including those caused by dengue and Zika viruses,...
Published: 2/6/2026
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Inventor(s): Adam Waickman, Stephen Thomas
Keywords(s): antibody therapy, infectious diseases, nucleic acid, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare
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Use of recombinant IgA1 isotype mAbs to prevent and antagonize transplacental transmission of flaviviruses in pregnant women
This technology is a single-chain IgA1 antibody delivered by DNA or RNA, enabling the body to produce its own dengue-neutralizing antibodies safely and quickly, without the risk of worsening infection, for rapid prevention and treatment of flavivirus diseases.
Background:
The field of flavivirus therapeutics, particularly for diseases like dengue,...
Published: 2/6/2026
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Inventor(s): Adam Waickman, Stephen Thomas
Keywords(s): infectious diseases, monoclonal antibodies, pregnancy, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare
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DEVICE FOR ORAL FLUID COLLECTION CONSISTING OF ABSORBANT MATERIAL AND NESTED TUBES REQUIRING CENTRIFUGATION
This is a simple, low-cost device using absorbent material and nested tubes to collect clean, mucous-free oral fluid samples by centrifugation, making sample collection easier, more hygienic, and affordable for labs and research.
Background:
Oral fluid collection is an essential process in various fields, including clinical diagnostics, biomedical...
Published: 2/6/2026
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Inventor(s): Aaron Glass
Keywords(s): saliva, Salivary biomarkers, specimen collection, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics
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HistoTME: an AI tool for prediction of the tumor microenvironment molecular composition from histopathology images
HistoTME is an AI software that predicts the tumor microenvironment’s molecular makeup from standard pathology images, helping identify lung cancer patients likely to benefit from immunotherapy without needing costly molecular tests.
Background:
The tumor microenvironment (TME) plays a crucial role in the progression and treatment response...
Published: 2/3/2026
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Inventor(s): Tamara Jamaspishvili, Sushant Patkar, Alex Chen, Stephanie Harmon, Ismail Turkbey
Keywords(s): artificial intelligence, cancer, computational biology, digital image processing, disease diagnosis, Technologies
Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University, Technology Classifications > Medical Imaging
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Pharmacological strategy to treat hydrocephalus
This technology offers a non-surgical treatment for hydrocephalus by using drugs to enhance the removal of harmful macromolecules from the brain’s ventricles, targeting specific cellular transport mechanisms to reduce fluid buildup and disease progression.
Background:
Hydrocephalus is a neurological disorder characterized by the abnormal accumulation...
Published: 1/29/2026
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Inventor(s): Satish Krishnamurthy, David Lehmann
Keywords(s): hydrocephalus, pharmacology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare
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“Smart” Electronic Rotating Hemostatic Valve and Tuohy-Borst Adapter with Integrated Activation and Force Sensors with Interface with Heads-Up Electronic Displays and Cloud-Based Data Analysis To Optimize Technical Safety, Display Live Quantified Operator Variables and Inform Individualized Procedural Technique
This technology measures, records, and displays force measurements exerted on catheters, providing valuable data to improve patient outcomes.
Background:
Rotating hemostatic valves (RHV) and Tuohy-Borst adapters (TBA) are used with catheter-based and other relevant procedures. Currently available RHVs and TBAs lack integrated sensors to provide feedback...
Published: 1/29/2026
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Inventor(s): Hesham Masoud, Andrew Decker
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare
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Self-delivery USP10 siRNA to promote regenerative healing-new IP
This technology employs an engineered self-delivering siRNA to selectively reduce USP10 protein levels in tissues, thereby promoting regenerative healing and suppressing pathological scarring. Preclinical studies in the eye demonstrate a favorable safety profile and robust efficacy, supporting the potential of this approach for treating fibrotic disease...
Published: 1/29/2026
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Inventor(s): Audrey Bernstein, Sean McCauley, Alexey Wolfson, Tere Williams
Keywords(s): fibrosis, opthalmology, scarring, siRNA, skin diseases, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Campus > Upstate Medical University
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Lipid nanoparticles for targeted delivery of therapeutic agents in acute lung injury
This technology uses lung-targeting lipid nanoparticles to deliver a combination of anti-inflammatory and immune-modulating drugs directly to the lungs, offering a more effective and targeted treatment for acute lung injury and acute respiratory distress syndrome.
Background:
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...
Published: 1/29/2026
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Inventor(s): Yamin Li, Yuqin Men, Robert Cooney, Qinghe Meng
Keywords(s): acute lung injury, anti-inflammatory therapeutic, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
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Rapid, robust, and near point-of-care saliva-based nucleic acid detection of dengue virus infections
This technology enables rapid, non-invasive detection and differentiation of all four dengue virus serotypes using saliva samples, with advanced qPCR and RT-LAMP assays, making dengue diagnosis easier, faster, and more accessible without the need for blood draws.
Background:
Dengue virus (DENV) is a major global health concern, with hundreds of millions...
Published: 1/29/2026
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Inventor(s): Frank Middleton, Stephen Thomas, Adam Waickman, Timothy Rooney
Keywords(s): diagnostics, disease diagnosis, isothermal amplification (LAMP), nucleic acid, PCR, RNA viruses, saliva, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Screens and Assays, Technology Classifications > Biomedical Science and Engineering
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Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells
This technology uses specially designed sulfonium lipid nanoparticles to deliver mRNA directly to lung cells through the nose, offering a non-invasive, more effective and targeted treatment for pulmonary diseases like asthma and cystic fibrosis.
Background:
The field of pulmonary medicine faces significant challenges in the treatment of diseases...
Published: 1/29/2026
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Inventor(s): Yamin Li, Yuqin Men
Keywords(s): active pharmaceutical ingredient, chemicals, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery
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