Engineered Telodendrimer Nanocarriers for Monomeric Amphotericin B Delivery
A nanocarrier platform for Amphotericin B that improves efficacy and reduces cost, while decreasing toxicity.
Background:
Systemic fungal infections are an increasingly prevalent health problem. The hydrophobic polyene antibiotic Amphotericin B (AmB) is the drug of choice for these life-threatening invasive fungal infections. Unfortunately, it produces...
Published: 4/1/2025
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Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines
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Discovery of Novel SHIP1 Agonists
A new class of SHIP1 agonists that offer the potential for the development of new treatments for a variety of diseases.
Background:
An agonist is a drug or substance that binds to a cell receptor, producing the same action as the substance that would naturally bind to the receptor. Agonists form the basis for a wide variety of therapeutics. The...
Published: 4/1/2025
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Inventor(s): William Kerr, Sandra Denney
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Artificial Intelligence, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare
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Purification of Human β and γ Actin from Budding Yeast
Provides easily accessible and relatively abundant sources of human β- or γ-actin.
Background:
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. In vertebrates, three main groups of actin isoforms (alpha, beta and gamma) have been identified. Alpha actins...
Published: 4/1/2025
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Inventor(s): David Amberg, Brian Haarer, Jessica Henty-Ridilla
Keywords(s): cytoplasmic actin, non-muscle actin, Technologies, β-actin, γ-actin
Category(s): Campus > Upstate Medical University, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents
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Multiplexed Saliva-based Immunodiagnostics for Assessing Anti-flavivirus Immunity
An easy-to-use method for rapidly, accurately, and non-invasively assessing flavivirus immunity by measuring various antibody classes present in saliva.
Background:
Flaviviruses (including dengue virus) are the most common vector-borne human viral pathogens in the world. Nearly 40% of the world’s population are at risk of infection with dengue...
Published: 4/1/2025
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Inventor(s): Adam Waickman, Stephen Thomas, Frank Middleton
Keywords(s): antibodies, antibody, infectious diseases, saliva, Technologies, viral immunology
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Injectable Nanogel for Immune Modulation Therapy
A platform for effective therapeutic delivery and immune modulation for effective and quick inflammation control in critical illness, including sepsis.
Background:
Immune modulation therapy is a type of immunotherapy that enhances the body’s immune regulation and homeostasis. This therapy has proved promising for the treatment of some types...
Published: 4/1/2025
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Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Stratification Method that Determines the Prognosis of Breast Cancer at a Personalized Level
A reliable, accurate, and versatile method for determining the prognosis of primary breast cancer tumors post-surgery.
Background:
Breast cancer is the second most common type of cancer in women in the United States, after skin cancer. On rare occasions, it can also occur in men. According to the American Cancer Society, nearly 300,000 new cases...
Published: 4/1/2025
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Inventor(s): Vladimir Kuznetsov, Leszek Kotula
Keywords(s): biomarkers, biostatistics, breast cancer, diagnostics, functional genomics, gene expression analysis, oncology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Medical Devices
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Balloon Assisted Thrombectomy Dual Aspiration and Distal Access Catheter System for Neurovascular Thrombectomy and Intracranial Emboli Protection
Improves the treatment of acute ischemic stroke by reducing the risk of distal thromboembolism and intercranial emboli.
Background:
Large vessel occlusion accounts for 30% of acute ischemic stroke (AIS) and is a major cause of devastating neurologic deficits. A large vessel occlusion (LVO) occurs when a large blood vessel carrying oxygen and nutrients...
Published: 4/1/2025
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Inventor(s): Hesham Masoud
Keywords(s): medical devices, Technologies
Category(s): Technology Classifications > Medical Devices, Campus > Upstate Medical University
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IgA Monoclonal Antibodies as a Prophylactic and Therapeutic Treatment for Dengue Virus Infection
Enables the prevention and treatment of dengue by avoiding the challenge of Antibody Dependent Enhancement. Background: Dengue virus is one of the most widespread vector-borne viral pathogens in the world. Nearly 400 million dengue virus infections occur each year, resulting in approximately 20,000 deaths. In addition, dengue-associated illness comprises...
Published: 4/1/2025
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Inventor(s): Adam Waickman, Adam Wegman
Keywords(s): antibody, antibody therapy, biologics, biomedical, disease prevention, immunotherapy, monoclonal antibody, Technologies, viral immunology, viral pathogenesis
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies, Technology Classifications > Healthcare, Technology Classifications > Viral Vectors, Campus > Upstate Medical University
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Tibial Tubercle Osteotomy Fixation Device
Fixation device to secure bone fragment of tibial tuberosity to native bone after osteotomy surgical procedure.
Background:
Standard osteotomy techniques to join the tibial tubercle fragment to native bone include screw fixation alone or fixation with wire or suture, which are not reliable methods to holding the bone in place to avoid displacement...
Published: 4/1/2025
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Inventor(s): Timothy Damron
Keywords(s): biomedical, biomedical engineering, hardware, healthcare, instrumentation, medical devices, medical equipment, orthopedics, osteoarthritis, surgery, suturing technique, Technologies
Category(s): Technology Classifications > Medical Devices, Campus > Upstate Medical University
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Drill Guide/Suture Passer for Posterior Approach Total Hip Soft Tissue Repair
Combined drill guide and suture passer for use in assisting repair following posterior approach total hip arthroplasty.
Background:
The posterior approach to the hip for total hip replacement as well as trauma, pediatric orthopedic surgery, and tumors is the most common approach for total hip arthroplasties. However, the performance of this...
Published: 4/1/2025
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Inventor(s): Timothy Damron
Keywords(s): biomedical engineering, biotechnology, hardware, healthcare, medical devices, medical equipment, orthopedics, surgery, suturing technique, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Medical Devices
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