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Nucleic Acids that Encode Sodium Channels

Provides a method for screening compounds for use as anti-arrhythmic agents and other medications using mutant mammalian voltage-gated sodium channel subunit. Background: Mammalian voltage-gated sodium channels are pore-forming membrane proteins responsible for the initiation and propagation of actions in nerve, skeletal muscle, and heart cells. The...
Published: 1/29/2024   |   Inventor(s): Sho-Ya Wang
Keywords(s):  
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Technology Classifications > Drug Delivery

Production of Salivary Gland Epithelial Progenitors and Acinar Organoids

Human UPSC-based tissue engineering system to develop salivary gland epithelial progenitors used to construct acinar organoids that mimic glandular microarchitecture and function. Background: Organoids are three-dimensional cell constructs that replicate the complicated tissue microarchitecture of specialized epithelial tissues. These constructs...
Published: 3/8/2024   |   Inventor(s): Stelios Andreadis, Ronel Samuel, Olga Baker, Kihoon Nam
Keywords(s): Biomedical Engineering, Biotechnology, Featured, Medical Devices, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Screens and Assays

Luminescent Biosensor for Detection of Specific Nucleotide Sequences, Small Molecules, and Proteins at Point-of-Care

A serotonin release assay that requires no special training or expensive equipment, and produces results within hours. Background: Platelet serotonin release assay (SRA) is a widely-used clinical assay for diagnosing heparin-induced thrombocytopenia (HIT), a life-threatening complication of heparin treatment. The current SRA procedure entails sending...
Published: 4/3/2024   |   Inventor(s): Stewart Loh, Harsimranjit Sekhon
Keywords(s): biomarker diagnostics, biosensor, detection, DNA nanoswitches, protein engineering, sensor, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines

A Rapid, High Content, Reagent Sparing, Fluorescent Plasmonic Assay Platform for Multiplexed Serum Antibody Detection in Lyme Disease and COVID-19

A protein microarray, in the form of a compact biochip, that can be analyzed with high sensitivity using GC-FP technology. Background: Some infectious diseases are easy to diagnose, but others are much more difficult. One example is Lyme disease (B. burgdorferi), which is caused by a slow-growing organism that takes many weeks to detect. Current...
Published: 1/17/2024   |   Inventor(s): Nathaniel Cady
Keywords(s): antibodies, assays, COVID-19, nanobioscience, nanobiotechnology, screens and assays, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Screens and Assays, Campus > SUNY Polytechnic Institute

Novel Cryoelectrospun Scaffolds for Tissue Engineering and Methods for Manufacturing

Methods to produce 3D nanofibrous scaffolds that closely mimic soft-tissue stromal ECM using a unique cryoelectrospinning process. Background: The extracellular matrix (ECM) comprising the proteinaceous scaffold within the connective tissue is involved in regulating the function of parenchymal tissue in organs. When that becomes stiff, or fibrotic,...
Published: 7/11/2023   |   Inventor(s): Susan Sharfstein, Yubing Xie, Pujhitha Ramesh, James Castracane, Melinda Larsen
Keywords(s): Technologies
Category(s): Campus > SUNY Polytechnic Institute, Technology Classifications > Screens and Assays, Campus > University at Albany

Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use

" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are diagnosed...
Published: 1/22/2024   |   Inventor(s): Li Niu, Zhen Huang
Keywords(s): Technologies
Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Campus, Campus > University at Albany

Human Trabecular Organ-on-a-Chip Models

3D biomimetic hydrogel models of the trabecular meshwork of the eye, and a bioengineered system for modelling the conventional outflow tract. Background: Models of the trabecular meshwork have largely been 2D up until now, but research has shown that 2D models of the TM behave differently -- sometimes in complete opposition -- to 3D models. A 3D model...
Published: 7/11/2023   |   Inventor(s): Samuel Herberg, Preethi Ganapathy, Haiyan Li
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Screens and Assays

Molecular Diagnosis and Prognosis of Carcinomas

A novel molecular marker that provides a reliable prognostic indicator for DCIS breast cancer patients. Background: Ductal carcinoma in situ (DCIS) is non-invasive type of breast cancer that occurs in the milk ducts, accounting for approximately 20% of new breast cancers. DCIS is non-invasive and not life-threatening. However, patients diagnosed...
Published: 7/11/2023   |   Inventor(s): Henri Tiedge
Keywords(s): breast cancer, Technologies
Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Diagnostics, Campus > SUNY Downstate Health Sciences University

ABI1 Regulates Transcriptional Activity of Androgen Receptor by Novel DNA and AR Binding Mechanism

Provides new pathways for biomarkers and drug discovery for cancer patients. Background: The gene Abelson interactor protein-1 (ABI1) encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal...
Published: 4/11/2024   |   Inventor(s): Leszek Kotula, Alaji Bah
Keywords(s): DNA, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines

Pancreatitis Associated Proteins as a Treatment for Pancreatic Diseases

A novel method for developing diagnostic tools and treatments for pancreatitis through the use of a truncated pancreatitis-associated protein (PAP). Background: Acute pancreatitis ranges in severity from a mild, self-limiting course treated with conservative methods, to a more aggressive variety causing sepsis, pancreatic necrosis, and hemorrhage....
Published: 7/11/2023   |   Inventor(s): Martin Bluth, Michael Zenilman
Keywords(s): Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines
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