Tools to Predict Clinical Immunogenicity
In vitro tools for predicting clinical immunogenicity of subcutaneously administered antigens, whether for therapeutic or prophylactic applications.
Background:
Immunogenicity, the propensity of a product to elicit an immune response to itself or related structures, may be desirable (e.g. vaccine candidates) or undesirable...
Published: 7/9/2026
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Inventor(s): Sathy Balu-Iyer, Aditi Venkatesh
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Use of Blood Nitric Oxide Responses as a Biomarker of Obesity and its Associated Conditions, including Allergy and Asthma
This technology offers a novel method for identifying individuals at increased risk for systemic inflammatory disorders, such as asthma, by measuring intracellular nitric oxide synthase expression in specific immune cells.
Background:
Asthma and other systemic inflammatory disorders often present challenges in effective diagnosis and management due...
Published: 6/12/2026
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Inventor(s): Rauno Joks, Maja Nowakowski, Helen Durkin (Deceased)
Keywords(s): Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Screens and Assays
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Novel Test for Non-HLA-based-rejection in Organ Transplantation
Luminex-based immunoassay for prediction of non-HLA determinants of kidney transplant graft rejection
Background:
End-stage kidney disease, also known as end-stage renal disease or kidney failure, affects over 800,000 people in the US. It is rapidly fatal without treatment, but can be treated palliatively with dialysis or curatively by kidney transplant....
Published: 6/19/2026
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Inventor(s): Lakshmanan Suresh, John Tomaszewski
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Diagnostics, Technology Classifications > Screens and Assays
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Production of Salivary Gland Epithelial Progenitors and Acinar Organoids
Human iPSC-based tissue engineering system to develop salivary gland epithelial progenitors used to construct acinar organoids that mimic glandular microarchitecture and function.
Background:
Organoids are three-dimensional cell constructs that replicate the complicated tissue microarchitecture of specialized epithelial tissues. These constructs...
Published: 6/19/2026
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Inventor(s): Stylianos Andreadis, Ronel Zachariah Samuel, Olga Baker, Kihoon Nam
Keywords(s): Biomedical Engineering, Biotechnology, Medical Devices, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Screens and Assays
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Fluorescent Peptides for Membrane Tension Reporting and Biomarkers
A peptide-based probe technology that enables real-time, non-invasive fluorescent detection and quantitation of cell membrane tension.
Background:
The 2021 Nobel Prize in Physiology or Medicine was awarded for the discovery of Piezo channels, mechanosensitive ion channels that respond to cell membrane tension, translating mechanical force directly...
Published: 6/19/2026
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Inventor(s): Thomas Suchyna, Sergei Sukharev
Keywords(s): Featured, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Biological Materials
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Bioprinting of collagenous bioinks
050-9518 Rapidly Synthesized Extracellular Matrix-Based Gels and Patterning Techniques, from Micro- to Macro-Scale/Bioprinting of Collagenous Bioinks
A method for bioprinting physiological materials, enabling rapid and precise 3D patterning of structures
Background:
Biological tissues are characterized by intricate 3D patterns of cells and extracellular...
Published: 5/5/2026
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Inventor(s): Michael Mak
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Campus > Stony Brook University
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Rapid, robust, and near point-of-care saliva-based nucleic acid detection of dengue virus infections
This technology enables rapid, non-invasive detection and differentiation of all four dengue virus serotypes using saliva samples, with advanced qPCR and RT-LAMP assays, making dengue diagnosis easier, faster, and more accessible without the need for blood draws.
Background:
Dengue virus (DENV) is a major global health concern, with hundreds of millions...
Published: 3/9/2026
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Inventor(s): Frank Middleton, Stephen Thomas, Adam Waickman, Timothy Rooney
Keywords(s): diagnostics, disease diagnosis, isothermal amplification (LAMP), nucleic acid, PCR, RNA viruses, saliva, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Screens and Assays, Technology Classifications > Biomedical Science and Engineering
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Method to Determine Quality of Mitochondrial Cargo in Extracellular Vesicles
A novel method that measures mitochondrial membrane potential in extracellular vesicles, providing a direct readout of mitochondrial quality and utility.
Background:
Studies have shown that EV-mediated intercellular communication is influenced, at least in part, by the mitochondrial cargo contained within EVs. This highlights the importance of rigorous...
Published: 6/19/2026
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Inventor(s): Barbara Alevriadou, Zahid Manzar, Hans Minderman
Keywords(s): Biotechnology, Diagnostic, Healthcare, Pharmaceutical, Research Tool, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Enhanced Fluorophore Discrimination in Fluorescence Microscopy Using Multi View Spectral Unmixing with Photobleaching Dynamics
This technology allows researchers to more easily distinguish hundreds of fluorescent labels in a single image, useful for a wide variety of biological applications.
Background:
There are hundreds to thousands of different cells or other structures that can be labeled with fluorescent reporters in a biological sample, and then imaged on a fluorescence...
Published: 3/26/2026
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Inventor(s): Alex Valm, Yunlong Feng, Ruogu Wang
Keywords(s): fluorescence, fluoroscopy, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Bioinformatics, Technology Classifications > Artificial Intelligence, Technology Classifications > Imaging, Technology Classifications > Optics and Photonics, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Healthcare, Technology Classifications > Diagnostics, Technology Classifications > Dental
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Glycosyltransferase Mutation-Activity Landscape
A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases
Background:
Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...
Published: 6/19/2026
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Biotechnology, Diagnostic, Pharmaceutical, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering
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