Enhanced Fluorophore Discrimination in Fluorescence Microscopy Using Multi View Spectral Unmixing with Photobleaching Dynamics
This technology allows researchers to more easily distinguish hundreds of fluorescent labels in a single image, useful for a wide variety of biological applications.
Background:
There are hundreds to thousands of different cells or other structures that can be labeled with fluorescent reporters in a biological sample, and then imaged on a fluorescence...
Published: 5/13/2025
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Inventor(s): Alex Valm, Yunlong Feng, Ruogu Wang
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Bioinformatics, Technology Classifications > Artificial Intelligence, Technology Classifications > Imaging, Technology Classifications > Optics and Photonics, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Healthcare, Technology Classifications > Diagnostics, Technology Classifications > Dental
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Luminescent Biosensor for Detection of Specific Nucleotide Sequences, Small Molecules, and Proteins at Point-of-Care
A serotonin release assay that requires no special training or expensive equipment, and produces results within hours. Background:
Platelet serotonin release assay (SRA) is a widely-used clinical assay for diagnosing heparin-induced thrombocytopenia (HIT), a life-threatening complication of heparin treatment. The current SRA procedure entails sending...
Published: 5/13/2025
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Inventor(s): Stewart Loh, Harsimranjit Sekhon
Keywords(s): biomarker diagnostics, biosensor, detection, DNA nanoswitches, protein engineering, sensor, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines
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A Rapid, High Content, Reagent Sparing, Fluorescent Plasmonic Assay Platform for Multiplexed Serum Antibody Detection in Lyme Disease and COVID-19
A protein microarray, in the form of a compact biochip, that can be analyzed with high sensitivity using GC-FP technology.
Background:
Some infectious diseases are easy to diagnose, but others are much more difficult. One example is Lyme disease (B. burgdorferi), which is caused by a slow-growing organism that takes many weeks to detect. Current...
Published: 5/13/2025
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Inventor(s): Nathaniel Cady
Keywords(s): antibodies, assays, COVID-19, nanobioscience, nanobiotechnology, screens and assays, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Screens and Assays, Campus > SUNY Polytechnic Institute
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Novel Cryoelectrospun Scaffolds for Tissue Engineering and Methods for Manufacturing
Methods to produce 3D nanofibrous scaffolds that closely mimic soft-tissue stromal ECM using a unique cryoelectrospinning process. Background: The extracellular matrix (ECM) comprising the proteinaceous scaffold within the connective tissue is involved in regulating the function of parenchymal tissue in organs. When that becomes stiff, or fibrotic,...
Published: 5/13/2025
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Inventor(s): Susan Sharfstein, Yubing Xie, Pujhitha Ramesh, James Castracane, Melinda Larsen
Keywords(s): Technologies
Category(s): Campus > SUNY Polytechnic Institute, Technology Classifications > Screens and Assays, Campus > University at Albany
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Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use
" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are diagnosed...
Published: 5/13/2025
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Inventor(s): Li Niu, Zhen Huang
Keywords(s): Technologies
Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Campus, Campus > University at Albany
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Nucleic Acids that Encode Sodium Channels
Provides a method for screening compounds for use as anti-arrhythmic agents and other medications using mutant mammalian voltage-gated sodium channel subunit.
Background:
Mammalian voltage-gated sodium channels are pore-forming membrane proteins responsible for the initiation and propagation of actions in nerve, skeletal muscle, and heart cells. The...
Published: 5/13/2025
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Inventor(s): Sho-Ya Wang
Keywords(s):
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Technology Classifications > Drug Delivery
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Human Trabecular Organ-on-a-Chip Models
3D biomimetic hydrogel models of the trabecular meshwork of the eye, and a bioengineered system for modelling the conventional outflow tract. Background: Models of the trabecular meshwork have largely been 2D up until now, but research has shown that 2D models of the TM behave differently -- sometimes in complete opposition -- to 3D models. A 3D model...
Published: 5/13/2025
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Inventor(s): Samuel Herberg, Preethi Ganapathy, Haiyan Li
Keywords(s):
Category(s): Campus > Upstate Medical University, Technology Classifications > Screens and Assays
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Molecular Diagnosis and Prognosis of Carcinomas
A novel molecular marker that provides a reliable prognostic indicator for DCIS breast cancer patients.
Background:
Ductal carcinoma in situ (DCIS) is non-invasive type of breast cancer that occurs in the milk ducts, accounting for approximately 20% of new breast cancers. DCIS is non-invasive and not life-threatening. However, patients diagnosed...
Published: 5/13/2025
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Inventor(s): Henri Tiedge
Keywords(s): breast cancer, Technologies
Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Diagnostics, Campus > SUNY Downstate Health Sciences University
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Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 5/13/2025
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Production of Salivary Gland Epithelial Progenitors and Acinar Organoids
Human iPSC-based tissue engineering system to develop salivary gland epithelial progenitors used to construct acinar organoids that mimic glandular microarchitecture and function.
Background:
Organoids are three-dimensional cell constructs that replicate the complicated tissue microarchitecture of specialized epithelial tissues. These constructs...
Published: 5/13/2025
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Inventor(s): Stelios Andreadis, Ronel Samuel, Olga Baker, Kihoon Nam
Keywords(s): Biomedical Engineering, Biotechnology, Featured, Medical Devices, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Screens and Assays
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