Bruton's Tyrosine Kinase as Anti-Cancer Drug Target
This technology identifies Bruton's Tyrosine Kinase (BTK) as a novel target in breast cancer therapy and provides methods for treatment and diagnosis by inhibiting a specific BTK variant.
Background:
Protein tyrosine kinases (PTKs) are essential enzymes involved in cellular communication and regulation, often playing a significant role in cancer...
Published: 5/5/2026
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Inventor(s): Douglas Conklin, Antonis Kourtidis, Cheryl Eifert
Keywords(s): breast cancer, cancer, TAF, Technologies, therapeutic targets
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany
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A layer-by-layer mass spectrometry intensity method for de novo direct sequencing of RNA therapeutics and impurities
3D NGMS-Seq is a mass spectrometry-based technology that accurately sequences all RNA types and impurities in mixed samples, enabling comprehensive analysis of RNA therapeutics for drug development, quality control, and regulatory compliance.
Background:
The field of RNA-based therapeutics has experienced rapid growth due to the success of mRNA vaccines...
Published: 5/5/2026
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Inventor(s): Shenglong Zhang
Keywords(s): Mass spectrometry imaging, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Bioinformatics, Technology Classifications > Therapeutics and Vaccines
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Developing a new mechanism-based method to treat behavioral variant frontotemporal dementia
This technology offers a novel, mechanism-based therapeutic method using oxytocin and specific compounds to treat social-affective deficits in behavioral variant frontotemporal dementia (bvFTD).
Background:
Behavioral variant frontotemporal dementia (bvFTD) is a prevalent form of dementia characterized by severe social and emotional impairments,...
Published: 3/30/2026
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Inventor(s): Wei-Dong Yao
Keywords(s): dementia, electrophysiology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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β-Catenin agonists recapitulate the protective effects of genetic stabilization
This technology uses drugs that stabilize β-catenin to boost protective immune cells in the lungs, reducing damage from pulmonary hemorrhage and inflammatory lung diseases by activating a novel immunomodulatory pathway.
Background:
Pulmonary hemorrhage and other inflammatory lung diseases represent significant clinical challenges due to their...
Published: 4/22/2026
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Inventor(s): Mobin Karimi
Keywords(s): gene coding, gene therapies, gene therapy, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
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Harnessing IL15C and NKG2D for Potent and Persistent CAR T Cell Therapy in TNBC
This technology is an advanced CAR T-cell therapy for triple-negative breast cancer that uses engineered T-cells to recognize and kill cancer cells regardless of HLA status and includes a built-in IL-15 signal to boost T-cell survival and effectiveness.
Background:
Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype of breast...
Published: 3/30/2026
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Inventor(s): Mobin Karimi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
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Apelin-Receptor (APJ) Antagonists
A series of stable, small molecule compounds that inhibit an alternative (non-VEGF) angiogenic pathway that is overexpressed in a variety of cancers.
Background:
Antiangiogenic drugs targeting the vascular endothelial growth factor (VEGF) signaling pathway are widely used to treat solid tumors and ocular conditions such as wet AMD. However, anti-VEGF...
Published: 4/16/2026
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Inventor(s): Youngjae You, Sukyung Woo, Ganesh Bist, Ahmed Elsheikh
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Drug Design and Synthesis
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Novel Fusion Protein Vaccine for Moraxella Catarrhalis Infections
A fusion protein vaccine designed to prevent COPD exacerbations and pediatric acute otitis media.
Background:
Respiratory infections caused by Moraxella catarrhalis (Mcat) represent a growing public health concern. In children, Mcat is a leading cause of otitis media, a common middle ear infection affecting most children by age three, frequently...
Published: 4/16/2026
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Inventor(s): Timothy Murphy, Patricia Weber
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies
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Peptide Therapeutic Against HIV
This technology presents a computationally evolved peptide therapeutic that targets human lysine tRNA to disrupt the HIV-1 replication cycle.
Background:
HIV-1 replication poses a significant challenge for therapeutic intervention due to the virus’s complex interaction with host cellular mechanisms. Existing treatments often face limitations...
Published: 3/27/2026
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Inventor(s): Paul Agris, Carol Hall, Xingqing Xiao
Keywords(s): HIV/AIDS, therapeutic targets
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Albany
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Netrin-4–Mediated Disruption of Basement Membranes for Targeted Therapeutic Delivery
Novel tools that promote the delivery of therapeutics to treat inner retinal diseases such as diabetic retinopathy, retinal vein occlusion, and retinitis pigmentosa.
Background:
Non-surgical access to tissues for direct biological manipulation, e.g. gene transfer, stem cell transplantation, and drug delivery, can be difficult because many tissues...
Published: 3/9/2026
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Inventor(s): Dale Hunter, William Brunken, Peter Yurchenco, Karen Mckee
Keywords(s): biologic therapies, drug delivery component, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines
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Dual Inhibition of RNA Polymerase I and III as a Novel Strategy for Targeting Ribosome Biogenesis in Cancer
A specially designed peptide blocks two key enzymes needed for ribosome production in cancer cells, shutting down their protein-making machinery and offering a new, more effective way to treat cancer and prevent drug resistance.
Background:
Ribosome biogenesis is a fundamental cellular process involving the coordinated synthesis of ribosomal RNA...
Published: 3/26/2026
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Inventor(s): Haleigh Pascual, Bruce Knutson
Keywords(s): cancer, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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