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Treatment of L-DOPA-induced Dyskinesia in Parkinson’s Disease

Repurposed antidepressant agents for treating levodopa-induced dyskinesia in Parkinson's disease Background: Dopamine replacement therapy with L-DOPA remains the gold-standard treatment for the crippling movement disruptions affecting >10 million Parkinson’s Disease patients worldwide. However, L-DOPA therapies, especially after...
Published: 10/16/2020   |   Inventor(s): Christopher Bishop
Keywords(s):  
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > Binghamton University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare

Pyrazinamide: an Effective Agent for the Treatment of Leishmaniasis

Leishmaniasis is a disease that has been neglected by most of the developed world until now, despite the fact that it is the 2nd most prevalent parasitic disease after malaria in global disease burden. Formerly considered to be a tropical disease, infections are now emerging in general populations across Europe, North America and Austral-Asia. It’s...
Published: 9/17/2020   |   Inventor(s): John Welch, Susana Mendez, Michael Cynamon
Keywords(s): Chagas disease, leishmania major, leishmaniasis, pyrazinamide, tripanosomes
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Albany

Proprietary Doxorubicin Formulation Increases Survival and Safety Over Free Doxorubicin and Doxil

Doxorubicin (DOX) is a commonly used anticancer chemo drug, and its clinical use is associated with dose-limiting cardiotoxicity. It is used to treat a wide variety of cancers including leukemia, bone and Karposi sarcomas, multiple myeloma, and ovarian, breast, kidney, endometrial, liver and gastric cancers. Despite being a generic, the market for liposomal...
Published: 9/17/2020   |   Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): #SUNYresearch, Featured, Technologies
Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University

6-Mer Peptide for Anti-Cancer Therapeutic Use

A 6-mer peptide (Win6mer) has been designed which has potential as an anti-cancer therapeutic. The Win6mer disrupts MLL1 and SETd1A core complex assembly, but does not inhibit isolated SET domain activity. MLL I belongs to the SETI family of histone H3 lysine 4 (H3K4) methyltransferases, comprised of MLLl-4 and SETdlA/B. MLLl translocations are present...
Published: 9/17/2020   |   Inventor(s): Michael Cosgrove, Nilda Alicea-Velazquez, Stephen Shinsky
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University

Process of Treating Myopia by Modulating Retinal Signaling Pathways Underlying Retinal Response to Positive and Negative Optical Defocus

Myopia (nearsightedness) is the most common eye disorder, and is rapidly becoming one of the leading causes of blindness. At the current rate of myopia occurrences, more than half the population will be myopic by 2050. While myopia has already increased from effecting 25% of the U.S. to 58% as of 2014, over 80% of the populations of urban communities...
Published: 9/17/2020   |   Inventor(s): David Troilo
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines, Campus > SUNY College of Optometry

Mechanisms of Action of an Aqueous Extract of the Bark of a Plant Used to Treat Diabetes in the Democratic Republic of Congo

This processes extracts the bark of Musanga cecropioides and processes the bark into powder which can be administered to patients suffering from diabetes. The powder decreases fasting and post prandial hyperglycemia.
Published: 9/17/2020   |   Inventor(s): Webe Kadima
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > SUNY Oswego

A constituent purified from plant Arctium Lappa L as a novel cancer therapeutic

In the United States there were more than 1.5 million new diagnosed cancer cases, and approximately 577,000 cancer-related deaths in the U.S. in 2012, according to the American Cancer Society. The development and discovery of newer anticancer therapeutics are still urgently needed. For the past four decades, cancer treatments have commonly been derived...
Published: 9/17/2020   |   Inventor(s): Ying Huang, Qing Sun, M. Sheikh
Keywords(s): anticancer therapeutic, natural product extract
Category(s): Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

SHIP1 Inhibitors to Augment Blood Cell Production and Transplantation and Kill Cancer Cells

SUNY Upstate Medical University researchers have developed a class of small molecule compounds that show promise for treating multiple myeloma and myelosuppression that occurs with many cancer treatments. These drugs inhibit a gene called SHIP1 — a novel target in cancer treatment — and have been shown to kill cancer cells in the lab and...
Published: 9/17/2020   |   Inventor(s): William Kerr, John Chisholm
Keywords(s): ALS, Featured
Category(s): Technology Classifications > Biological Materials, Technology Classifications > Therapeutics and Vaccines

PreSight Technologies, Inc.

PreSight Technologies crafted a needle guide for fluoroscopic procedures to assist in more accurate needle procedures. www.presighttechnologies.com
Published: 9/26/2019   |   Inventor(s): Stony Brook University
Keywords(s): Startups
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Therapeutics and Vaccines, Campus > Stony Brook University

Nanobiotix

Nanobiotix uses therapeutic technologies based on physical principles at nanoscale to discover approaches to improving treatment outcomes. Nanobiotix designs and manufactures nanoparticles that safley enhance the efficiacy of radiation therapy in the treatment of cancer. This will improve the efficiency of radiation in tumor cells for patients and hopefully...
Published: 9/26/2019   |   Inventor(s): University at Buffalo
Keywords(s): Startups
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Nanotechnology, Campus > University at Buffalo
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