Regulatory BC200 RNA in Beast Cancer
This technology is a novel breast cancer treatment that uses small interfering RNAs to silence BC200 RNA.
Background:
Breast cancer incidence rates have been slowly but steadily increasing over the last two decades. Despite improvements in early detection methods and therapeutic interventions, breast cancer remains a leading cause of cancer death...
Published: 4/24/2025
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Inventor(s): Valerio Berardi, Henri Tiedge
Keywords(s): anticancer therapeutic, biomedical science, regulatory RNAs, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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Breast Cancer Therapeutic Using BC200 RNA Silencing Methods
This technology is a novel breast cancer treatment that uses small interfering RNAs to silence BC200 RNA.
Background:
Breast cancer incidence rates have been slowly but steadily increasing over the last two decades. Despite improvements in early detection methods and therapeutic interventions, breast cancer remains a leading cause of cancer death...
Published: 4/24/2025
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Inventor(s): Valerio Berardi, Henri Tiedge
Keywords(s): breast cancer, RNA modifications, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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RNA-aptamer-mediated Bacteriophage Purification
A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes.
Background:
Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...
Published: 4/1/2025
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Inventor(s): Ing-Nang Wang, Hua Shi, Jia Sheng, Alan Chen
Keywords(s): bacteriophage purification, phage purification, phage therapy, RNA aptamer, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
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Engineered Telodendrimer Nanocarriers for Monomeric Amphotericin B Delivery
A nanocarrier platform for Amphotericin B that improves efficacy and reduces cost, while decreasing toxicity.
Background:
Systemic fungal infections are an increasingly prevalent health problem. The hydrophobic polyene antibiotic Amphotericin B (AmB) is the drug of choice for these life-threatening invasive fungal infections. Unfortunately, it produces...
Published: 4/1/2025
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Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines
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Raman Spectroscopy for Testing Stability of RNA-based Vaccines and Drugs
A fast, less expensive, and more reliable method for assessing mRNA degradation in vaccines, that can also be used as a tool for the development of new RNA-based therapeutics.
Background:
The development of mRNA-based vaccines for COVID-19 offers the potential for a new medical paradigm based on RNA technology. Unfortunately, these drugs require...
Published: 4/1/2025
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Inventor(s): Igor Lednev, Alexander Shekhtman, Lamyaa Almehmadi, Sergei Reverdatto
Keywords(s): drug stability, mRNA, mRNA stability, Raman spectroscopy, RNA, Technologies, vaccine stability, vaccines
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Viral Vectors
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Multiplexed Saliva-based Immunodiagnostics for Assessing Anti-flavivirus Immunity
An easy-to-use method for rapidly, accurately, and non-invasively assessing flavivirus immunity by measuring various antibody classes present in saliva.
Background:
Flaviviruses (including dengue virus) are the most common vector-borne human viral pathogens in the world. Nearly 40% of the world’s population are at risk of infection with dengue...
Published: 4/1/2025
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Inventor(s): Adam Waickman, Stephen Thomas, Frank Middleton
Keywords(s): antibodies, antibody, infectious diseases, saliva, Technologies, viral immunology
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Algorithm for Identifying Images of Fluorescently-Labeled Cells
Improves the ability to distinguish multiple fluorophores with overlapping emission spectra in biological images of labeled cells by a factor of two or more.
Background:
Cells (including normal and tumor cells), tissues, microbial communities, and other biological systems generally consist of multiple interacting components, especially proteins...
Published: 4/1/2025
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Inventor(s): Alex Valm, Yunlong Feng
Keywords(s): bacterial cells, bacterial infection, bioengineering, biofilm control, bioinformatics, biomarker diagnostics, biomarkers, cancer, cell biology, computational biology, dental, diagnostics, digital image processing, fluorescence, fluorescence spectroscopy, gene expression analysis, image analysis, image processing, machine learning, medical imaging, microbial pathogenesis, personalized medicine, RNA, saliva, scanning microscopy, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Viral Vectors
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Injectable Nanogel for Immune Modulation Therapy
A platform for effective therapeutic delivery and immune modulation for effective and quick inflammation control in critical illness, including sepsis.
Background:
Immune modulation therapy is a type of immunotherapy that enhances the body’s immune regulation and homeostasis. This therapy has proved promising for the treatment of some types...
Published: 4/1/2025
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Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Production of Cyclic Macrocycle Library for Rapid High Throughput Evaluations in Aqueous Medium
Produces cyclic peptide libraries quickly, cheaply, and without the need of purification.
Background:
Cyclic peptides are a class of molecules with important biological activities that could provide substantial medical benefit. Cyclic peptides are often used to develop therapeutic agents and biochemical tools. Unfortunately, the most common method...
Published: 4/1/2025
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Inventor(s): Qiang Zhang, Huan Chen
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
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Treatment of Neuropsychiatric Lupus
Directly targets autoimmune antibodies that cause lupus-related seizures and cognitive impairment. Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder with poorly understood etiology and no significantly effective treatment. The Lupus Foundation of America estimates that 1.5 million Americans, and at least five million...
Published: 4/1/2025
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Inventor(s): Henri Tiedge, Ilham Muslimov, Ellen Ginzler
Keywords(s): lupus, regulatory RNAs, seizures, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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