Peptide Therapeutic Against HIV
This technology presents a computationally evolved peptide therapeutic that targets human lysine tRNA to disrupt the HIV-1 replication cycle.
Background:
HIV-1 replication poses a significant challenge for therapeutic intervention due to the virus’s complex interaction with host cellular mechanisms. Existing treatments often face limitations...
Published: 3/9/2026
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Inventor(s): Paul Agris, Carol Hall, Xingqing Xiao
Keywords(s): HIV/AIDS, therapeutic targets
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Albany
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Netrin-4–Mediated Disruption of Basement Membranes for Targeted Therapeutic Delivery
Novel tools that promote the delivery of therapeutics to treat inner retinal diseases such as diabetic retinopathy, retinal vein occlusion, and retinitis pigmentosa.
Background:
Non-surgical access to tissues for direct biological manipulation, e.g. gene transfer, stem cell transplantation, and drug delivery, can be difficult because many tissues...
Published: 3/9/2026
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Inventor(s): Dale Hunter, William Brunken, Peter Yurchenco, Karen Mckee
Keywords(s): biologic therapies, drug delivery component, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines
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Dual Inhibition of RNA Polymerase I and III as a Novel Strategy for Targeting Ribosome Biogenesis in Cancer
A specially designed peptide blocks two key enzymes needed for ribosome production in cancer cells, shutting down their protein-making machinery and offering a new, more effective way to treat cancer and prevent drug resistance.
Background:
Ribosome biogenesis is a fundamental cellular process involving the coordinated synthesis of ribosomal RNA...
Published: 3/13/2026
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Inventor(s): Haleigh Pascual, Bruce Knutson
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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RNA-aptamer-mediated Bacteriophage Purification
A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes.
Background:
Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...
Published: 3/20/2026
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Inventor(s): Ing-Nang Wang, Hua Shi, Jia Sheng, Alan Chen
Keywords(s): bacteriophage purification, phage purification, phage therapy, RNA aptamer, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
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Raman Spectroscopy for Testing Stability of RNA-based Vaccines and Drugs
A fast, less expensive, and more reliable method for assessing mRNA degradation in vaccines, that can also be used as a tool for the development of new RNA-based therapeutics.
Background:
The development of mRNA-based vaccines for COVID-19 offers the potential for a new medical paradigm based on RNA technology. Unfortunately, these drugs require...
Published: 1/29/2026
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Inventor(s): Igor Lednev, Alexander Shekhtman, Lamyaa Almehmadi, Sergei Reverdatto
Keywords(s): drug stability, mRNA, mRNA stability, Raman spectroscopy, RNA, Technologies, vaccine stability, vaccines
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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Use of Quercetin and Related Flavonoids for the Treatment of Myotonic Dystrophy Types 1 and 2
A novel flavonoids-based therapeutic strategy for the treatment of myotonic dystrophy and potentially repeat expansion disorders. Background:
Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy. It is a multisystemic disorder affecting nearly all organs including muscles, brain, heart, eyes, and the GI tract, among others....
Published: 2/13/2026
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Inventor(s): John Berglund, Subodh Mishra, Kaalak Reddy, John Cleary
Keywords(s): drug discovery, drug efficacy, myotonic dystrophy, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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Reduction of Lipid Accumulation Reverses Aging
Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis.
Background:
Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 2/19/2026
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Inventor(s): Stelios Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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Antimicrobial Compositions and Combination Therapies
Compositions and methods to combat drug-resistant Pseudomonas aeruginosa infections.
Background:
Antibiotic resistance is an urgent and growing health threat. Pseudomonas aeruginosa is known to cause a variety of infections in both immunocompetent and immunocompromised individuals, but especially the latter. It utilizes both intrinsic and acquired...
Published: 2/19/2026
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Inventor(s): Mark Sutton, Brian Tsuji, Anthony Berdis
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines
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Regulatory BC200 RNA in Beast Cancer
This technology is a novel breast cancer treatment that uses small interfering RNAs to silence BC200 RNA.
Background:
Breast cancer incidence rates have been slowly but steadily increasing over the last two decades. Despite improvements in early detection methods and therapeutic interventions, breast cancer remains a leading cause of cancer death...
Published: 3/9/2026
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Inventor(s): Valerio Berardi, Henri Tiedge
Keywords(s): anticancer therapeutic, biomedical science, regulatory RNAs, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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Breast Cancer Therapeutic Using BC200 RNA Silencing Methods
This technology is a novel breast cancer treatment that uses small interfering RNAs to silence BC200 RNA.
Background:
Breast cancer incidence rates have been slowly but steadily increasing over the last two decades. Despite improvements in early detection methods and therapeutic interventions, breast cancer remains a leading cause of cancer death...
Published: 3/9/2026
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Inventor(s): Valerio Berardi, Henri Tiedge
Keywords(s): breast cancer, RNA modifications, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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