mAbs Inhibit Human RAGE by Blocking Its Binding to Heparan Sulfate
Monoclonal antibodies that block heparan sulfate binding to human RAGE, preventing its activation in disease states to serve as a therapeutic treatment.
Background:
Receptor for Advanced Glycation End products (RAGE), a widely expressed inflammatory receptor for disease states such as atherosclerosis, cancer, Alzheimer disease, drug-induced liver...
Published: 7/9/2024
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Inventor(s): Ding Xu, Chih Yean Ong, Miaomiao Li
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines
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Compositions and Methods for Increased Circulation Half-Life
Single domain antibody composition that enable half-life extension and increased blood:tissue ratios.
Background:
While strategies such as PEGylation (PEG, polyethylene glycol), albumin binding, and Fc-fusion have been employed to extend the half-life of biological and pharmaceutical agents, there remains a need for additional strategies that not...
Published: 11/21/2024
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Inventor(s): Brandon Bordeau, Joseph Balthasar, Toan Nguyen
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines
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IgA Monoclonal Antibodies as a Prophylactic and Therapeutic Treatment for Dengue Virus Infection
Enables the prevention and treatment of dengue by avoiding the challenge of Antibody Dependent Enhancement. Background: Dengue virus is one of the most widespread vector-borne viral pathogens in the world. Nearly 400 million dengue virus infections occur each year, resulting in approximately 20,000 deaths. In addition, dengue-associated illness comprises...
Published: 7/11/2023
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Inventor(s): Adam Waickman, Adam Wegman
Keywords(s): antibody, antibody therapy, biologics, biomedical, disease prevention, immunotherapy, monoclonal antibody, Technologies, viral immunology, viral pathogenesis
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies, Technology Classifications > Healthcare, Technology Classifications > Viral Vectors, Campus > Upstate Medical University
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Drug Discovery Based on Surface-Enhanced Raman Spectroscopy (SERS)
Enables drug discovery without introducing modifications to the molecules, while lowering costs by requiring only small amounts of the tested molecules.
Background:
Surface-enhanced Raman spectroscopy (SERS) is a novel, label-free, sensitive, specific, fast, and relatively inexpensive tool for drug discovery. It offers the potential to detect and...
Published: 3/12/2024
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Inventor(s): Igor Lednev, Lamyaa Almehmadi, Jia Sheng
Keywords(s): Raman spectroscopy, RNA, RNA chemistry, TAF, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Antibody Against Inositol 1,4,5-Trisphosphate Receptor Type 2 (anti-IP3R antibody)
Antibody against the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) type 2
Background: The inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is an intracellular Ca²⁺-release channel located on the endoplasmic reticulum (ER). IP3R2 is characterized by a high sensitivity to both IP3 and ATP and is biphasically regulated by Ca²⁺. Furthermore,...
Published: 1/3/2024
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Inventor(s): Richard Wojcikiewicz
Keywords(s): antibodies, antibody
Category(s): Technology Classifications > Antibodies, Campus > Upstate Medical University
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Easily Produced Nanoscale Hot Spots for More Sensitive Raman Scattering Using Liquid Metal Structures
A novel nanophotonic sensor that enhances Raman scattering signals by several orders of magnitude by creating nanoscale hot spots formed by liquid metal.
Background:
Analytes in the hot spots of such nanophotonic sensors will experience drastically enhanced interactions with the incident light, and therefore produce much more optical sensing signals....
Published: 7/9/2024
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Inventor(s): Peter Liu, Xianglong Miao, Shreyan Datta
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering
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Targeted Delivery of Matrix-Modulating Enzymes
For enhanced monoclonal antibody uptake and distribution in solid tumors.
Background:
Penetration of anti-tumor therapies is often limited by the tumor microenvironment, which can include a high density of extracellular matrix as well as elevated interstitial fluid pressure, both of which create a barrier to distribution. It is well established...
Published: 9/3/2024
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Inventor(s): Joseph Balthasar, Brandon Bordeau
Keywords(s): Technologies
Category(s): Technology Classifications, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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Development of a Pediatric Tuberculosis Diagnostic Test
A lipoprotein diagnostic marker for TB disease ideal for a simple diagnostic assay from a finger prick blood or serum Background: The inadequate sensitivity of available organism-based TB diagnostic tools in children, the wide spectrum of disease observed in children, and the non-specific signs and symptoms especially in young and HIV-children,...
Published: 2/28/2024
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Inventor(s): Nicole Sampson, Xinxin Yang
Keywords(s): antibody, biomarker, diagnosis, ELISA, modified LDL, Technologies, tuberculosis
Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Diagnostics
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Methods of Treating and Preventing Angioedema and Vascular Leakage
Peptides and antibodies that block vascular permeability induced in angioedema patients that are new targets for treatment. Background: Angioedema associated with C1-INH deficiency is an inherited or acquired condition that affects 20 per cent of the population. The condition can be disfiguring, painful and sometimes fatal. Existing treatments primarily...
Published: 10/3/2024
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Inventor(s): Berhane Ghebrehiwet
Keywords(s): angioedema, gClqR, Medical, Monoclonal antibody, peptides, Technologies, vascular leakage
Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Therapeutics
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Monoclonal Antibody, Anti Ft LVS LpnA/Tu14 Clone 164
An intracellular bacterium that can initiate the human response to Tularemia Background: Francisella tularensis is an intracellular, gram-negative bacterium that invades macrophages and initiates the human immune response. Technology Overview: Tularemia, commonly known as ?rabbit fever? can be communicated across several species including;...
Published: 10/3/2024
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Inventor(s): Jorge Benach, Anne Savitt
Keywords(s): Anti Ft LVS LpnA/Tul4 Clone 164, Biological or Antibody, Monoclonal antibody, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Research Tools and Reagents
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