Generation of a single-chain recombinant IgA1 isotype antibody compatible with in vivo nucleic acid delivery for the treatment and prevention of flavivirus infection
This technology uses a single-chain IgA1 antibody delivered by DNA or RNA to enable the body to produce its own protection against dengue and Zika viruses, offering rapid, safe, and scalable prevention and treatment without risk of antibody-dependent enhancement.
Background:
Flavivirus infections, including those caused by dengue and Zika viruses,...
Published: 2/13/2026
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Inventor(s): Adam Waickman, Stephen Thomas
Keywords(s): antibody therapy, infectious diseases, nucleic acid, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare
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Use of recombinant IgA1 isotype mAbs to prevent and antagonize transplacental transmission of flaviviruses in pregnant women
This technology is a single-chain IgA1 antibody delivered by DNA or RNA, enabling the body to produce its own dengue-neutralizing antibodies safely and quickly, without the risk of worsening infection, for rapid prevention and treatment of flavivirus diseases.
Background:
The field of flavivirus therapeutics, particularly for diseases like dengue,...
Published: 2/13/2026
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Inventor(s): Adam Waickman, Stephen Thomas
Keywords(s): infectious diseases, monoclonal antibodies, pregnancy, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare
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Easily Produced Nanoscale Hot Spots for More Sensitive Raman Scattering Using Liquid Metal Structures
A novel nanophotonic sensor that enhances Raman scattering signals by several orders of magnitude by creating nanoscale hot spots formed by liquid metal.
Background:
Analytes in the hot spots of such nanophotonic sensors will experience drastically enhanced interactions with the incident light, and therefore produce much more optical sensing signals....
Published: 10/22/2025
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Inventor(s): Peter Liu, Xianglong Miao, Shreyan Datta
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering
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An anti-capsular antibody that cross protects against clade 1 Carbapenem-resistant Klebsiella pneumoniae
A monoclonal antibody that exhibits cross-protective efficacy against multiple ST258 CR-Kp strains
RSS.HDBackground> Background: <
Therapeutic monoclonal antibodies (mAbs) have emerged as a dominant therapeutic modality to treat cancer, immune disorders, and infectious diseases such as high-mortality Carbapenem-resistant Klebsiella pneumoniae...
Published: 7/25/2025
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Inventor(s): Kasturi Banerjee, Bettina Fries, Michael Motley
Keywords(s):
Category(s): Technology Classifications > Antibodies, Campus > Stony Brook University
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IgA Monoclonal Antibodies as a Prophylactic and Therapeutic Treatment for Dengue Virus Infection
Enables the prevention and treatment of dengue by avoiding the challenge of Antibody Dependent Enhancement. Background: Dengue virus is one of the most widespread vector-borne viral pathogens in the world. Nearly 400 million dengue virus infections occur each year, resulting in approximately 20,000 deaths. In addition, dengue-associated illness comprises...
Published: 1/30/2026
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Inventor(s): Adam Waickman, Adam Wegman, Jeffrey Currier, Heather Friberg, Michael McCracken, Gregory Gromowski
Keywords(s): antibody, antibody therapy, biologics, biomedical, disease prevention, immunotherapy, monoclonal antibody, Technologies, viral immunology, viral pathogenesis
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies, Technology Classifications > Healthcare, Campus > Upstate Medical University
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Drug Discovery Based on Surface-Enhanced Raman Spectroscopy (SERS)
Enables drug discovery without introducing modifications to the molecules, while lowering costs by requiring only small amounts of the tested molecules.
Background:
Surface-enhanced Raman spectroscopy (SERS) is a novel, label-free, sensitive, specific, fast, and relatively inexpensive tool for drug discovery. It offers the potential to detect and...
Published: 1/30/2026
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Inventor(s): Igor Lednev, Lamyaa Almehmadi, Jia Sheng
Keywords(s): Raman spectroscopy, RNA, RNA chemistry, TAF, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Antibody Against Inositol 1,4,5-Trisphosphate Receptor Type 2 (anti-IP3R antibody)
Antibody against the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) type 2
Background: The inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is an intracellular Ca²⁺-release channel located on the endoplasmic reticulum (ER). IP3R2 is characterized by a high sensitivity to both IP3 and ATP and is biphasically regulated by Ca²⁺. Furthermore,...
Published: 1/30/2026
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Inventor(s): Richard Wojcikiewicz
Keywords(s): antibodies, antibody
Category(s): Technology Classifications > Antibodies, Campus > Upstate Medical University
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Compositions and Methods for Increased Circulation Half-Life
Single domain antibody composition that enable half-life extension and increased blood:tissue ratios.
Background:
While strategies such as PEGylation (PEG, polyethylene glycol), albumin binding, and Fc-fusion have been employed to extend the half-life of biological and pharmaceutical agents, there remains a need for additional strategies that not...
Published: 9/12/2025
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Inventor(s): Brandon Bordeau, Joseph Balthasar, Toan Nguyen
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines
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Targeted Delivery of Matrix-Modulating Enzymes
For enhanced monoclonal antibody uptake and distribution in solid tumors.
Background:
Penetration of anti-tumor therapies is often limited by the tumor microenvironment, which can include a high density of extracellular matrix as well as elevated interstitial fluid pressure, both of which create a barrier to distribution. It is well established...
Published: 10/22/2025
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Inventor(s): Joseph Balthasar, Brandon Bordeau
Keywords(s): Technologies
Category(s): Technology Classifications, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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Methods of Treating and Preventing Angioedema and Vascular Leakage
Peptides and antibodies that block vascular permeability induced in angioedema patients that are new targets for treatment. Background: Angioedema associated with C1-INH deficiency is an inherited or acquired condition that affects 20 per cent of the population. The condition can be disfiguring, painful and sometimes fatal. Existing treatments primarily...
Published: 7/28/2025
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Inventor(s): Berhane Ghebrehiwet
Keywords(s): angioedema, gClqR, Medical, Monoclonal antibody, peptides, Technologies, vascular leakage
Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies
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